Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500427 | 0.84 | NPC1 (0.47) | NPC1RAB9ACES2CES1PARP1 | |
| SCHEMBL17122434 | 0.83 | PARP1 (0.57) | NPC1RAB9ACES2CES1PARP1 | |
| SCHEMBL2770950 | 0.81 | NPC1 (0.63) | NPC1RAB9ACES2CES1PARP1 | |
| SCHEMBL5742776 | 0.81 | CES2 (0.53) | NPC1RAB9ACES2CES1PARP1 | |
| SCHEMBL15629599 | 0.79 | NQO2 (0.47) | CES2CES1PARP1PRSS1PRSS2 | |
| SCHEMBL4816445 | 0.79 | PDE4A (0.56) | NPC1RAB9ACES2CES1PARP1 | |
| SCHEMBL2769214 | 0.79 | NPC1 (0.56) | NPC1RAB9ACES2CES1PARP1 | |
| SCHEMBL1982164 | 0.78 | CES2 (0.50) | NPC1RAB9ACES2CES1PARP1 | |
| SCHEMBL8123810 | 0.78 | RAB9A (0.57) | NPC1RAB9ACES2CES1PARP1 | |
| SCHEMBL1987783 | 0.78 | PARP1 (0.46) | PARP1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643169-B1 | Process for the preparation of quinoline based ionic fluoride salts (QUFS) | HAMEED ABDUL (PK) | 2017-05-09 | — | — | US | disclosed |
| EP-2512242-B1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-30 | — | — | EP | disclosed |
| US-9029545-B2 | Thienopyridine NOX2 inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED (GB) | 2015-05-12 | — | — | US | disclosed |
| US-9029545-B2 | Thienopyridine NOX2 inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED (GB) | 2015-05-12 | — | — | US | disclosed |
| EP-2512242-A1 | NOVEL COMPOUNDS | Glaxo Wellcome Manufacturing Pte Ltd (SG) | 2012-10-24 | — | — | EP | disclosed |
| US-20120252805-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
| US-20120252805-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
| WO-2011075559-A1 | NOVEL COMPOUNDS | GLAXO WELLCOME MANUFACTURING PTE LTD. (SG) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011075559-A1 | NOVEL COMPOUNDS | GLAXO WELLCOME MANUFACTURING PTE LTD. (SG) | 2011-06-23 | — | — | WO | disclosed |
| EP-1171443-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL NV (NL) | 2005-07-13 | — | — | EP | disclosed |
| US-6841553-B2 | Bicyclic heteroaromatic compounds useful as LH agonists | AKZO NOBEL N.V. (NL) | 2005-01-11 | — | — | US | disclosed |
| US-20030212081-A1 | Bicyclic heteroaromatic compounds useful as LH agonists | MERCK SHARP & DOHME B.V. (NL) | 2003-11-13 | — | — | US | disclosed |
| US-6569863-B1 | Luteinizing hormone (LH) agonists for controlling fertility | AKZO NOBEL NV (NL) | 2003-05-27 | — | — | US | disclosed |
| EP-1171443-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | Akzo Nobel N.V. (NL) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061586-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL N.V. (NL) | 2000-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252805-A1 | NOVEL COMPOUNDS | CYBB, NOX1, NOX4 | NPC1 1920/4885RAB9A 2150/4885CES2 806/4885 |
| US-20030212081-A1 | Bicyclic heteroaromatic compounds useful as LH agonists | LHCGR, GNRHR, FSHR | NPC1 1152/4885RAB9A 3848/4885CES2 1456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.