SCHEMBL19822501

SCHEMBL19822501

CC(C)Nc1nc(Cl)nc(Cl)c1C=N

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
PDE10A Q9Y233 1/20 0.35
GLP1R P43220 1/20 0.33
ADORA3 P0DMS8 1/20 0.30
ADORA1 P30542 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21282844 0.81 CA1 (0.39) GAATDP1PDE10AGLP1R
SCHEMBL13535501 0.79 YTHDC1 (0.37)
SCHEMBL30332423 0.72 GAA (0.47) GAATDP1PDE10AGLP1RADORA3
SCHEMBL22873524 0.71
SCHEMBL10990458 0.70 GAA (0.45) GAATDP1PDE10AGLP1R
SCHEMBL19822682 0.70 KMT2A (0.36) PDE10AADORA3ADORA1
SCHEMBL11175610 0.68 RXFP1 (0.43) GAATDP1PDE10A
SCHEMBL1060590 0.67 CA1 (0.52) GAATDP1PDE10AGLP1R
SCHEMBL19346602 0.66 ALDH1A1 (0.32)
SCHEMBL11854675 0.66 DPP4 (0.44) GAATDP1PDE10AGLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2970266-B1 1-PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF EPIZYME INC (US) 2018-01-31 EP disclosed