Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 14/20 | 0.39 |
| ▸ | CA2 | P00918 | 14/20 | 0.39 |
| ▸ | CA12 | O43570 | 12/20 | 0.39 |
| ▸ | CA9 | Q16790 | 11/20 | 0.39 |
| ▸ | CA6 | P23280 | 10/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzthiazide SCHEMBL2452168 | 0.90 | ALDH1A1 (0.51) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL2449654 | 0.90 | ALDH1A1 (0.51) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL26257 | 0.89 | ALDH1A1 (0.63) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL936396 | 0.89 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL1276519 | 0.89 | ALDH1A1 (0.60) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL345215 | 0.89 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL7217920 | 0.89 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL9517821 | 0.89 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL7102453 | 0.89 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL6546528 | 0.89 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 419 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11965198-B2 | Method for producing target substance by bacterial fermentation | AJINOMOTO CO., INC. (JP) | 2024-04-23 | — | — | US | disclosed |
| EP-4291182-A1 | MICROBIAL ERGOTHIONEINE BIOSYNTHESIS | Conagen Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| US-20220010343-A1 | Method of Producing L-Amino Acids | AJINOMOTO CO., INC. (JP) | 2022-01-13 | — | — | US | disclosed |
| US-11198894-B2 | Method of producing an l-amino acid involving a carotenoid biosynthesis enzyme | AJINOMOTO CO., INC. (JP) | 2021-12-14 | — | — | US | disclosed |
| EP-3861109-A1 | METHOD FOR PRODUCING TARGET SUBSTANCE BY BACTERIAL FERMENTATION | AJINOMOTO CO., INC. (JP) | 2021-08-11 | — | — | EP | disclosed |
| WO-2021060438-A1 | METHOD FOR PRODUCING L-AMINO ACIDS BY BACTERIAL FERMENTATION | AJINOMOTO CO., INC. (JP) | 2021-04-01 | — | — | WO | disclosed |
| EP-3098319-B1 | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE FAMILY ENTEROBACTERIACEAE HAVING AN ATTENUATED EXPRESSION OF A GSHA GENE | AJINOMOTO KK (JP) | 2020-11-25 | — | — | EP | disclosed |
| WO-2020204179-A1 | METHOD OF PRODUCING L-AMINO ACIDS | AJINOMOTO CO., INC. (JP) | 2020-10-08 | — | — | WO | disclosed |
| EP-3385389-B1 | METHOD FOR PRODUCING L-AMINO ACIDS FROM FRUCTOSE | AJINOMOTO KK (JP) | 2020-10-07 | — | — | EP | disclosed |
| US-10787691-B2 | Method for producing L-amino acid | AJINOMOTO CO., INC. (JP) | 2020-09-29 | — | — | US | disclosed |
| US-20030199088-A1 | For the production of achromosomal archeabacterial, eubacterial and anucleate eukaryotic cells; for therapeutics, diagnostics, drug discovery, proteomics | VAXIION THERAPEUTICS, LLC | 2003-10-23 | — | — | US | disclosed |
| US-20030194714-A1 | Minicell-based transformation | MPEX BIOSCIENCES, INC. | 2003-10-16 | — | — | US | disclosed |
| US-20030194798-A1 | For diagnositic, therapeutic, research, and drug discovery applications | MPEX BIOSCIENCES, INC. | 2003-10-16 | — | — | US | disclosed |
| US-20030190749-A1 | Expression element that comprises a gene linked to sequences that are inducible and/or repressible; mutations; useful in diagnositics, therapeutics and drug discovery | MPEX BIOSCIENCES, INC. | 2003-10-09 | — | — | US | disclosed |
| US-20030190601-A1 | Useful for diagnosis and therapy, research tools for drug discovery | MPEX BIOSCIENCES, INC. | 2003-10-09 | — | — | US | disclosed |
| US-20030190683-A1 | Production of achromosomal and anucleate cells useful for diagnositic and therapeutic uses, as well as research tools and agents for drug discovery | MPEX BIOSCIENCES, INC. | 2003-10-09 | — | — | US | disclosed |
| US-20030166099-A1 | Minicells comprising membrane proteins | MPEX BIOSCIENCES, INC. | 2003-09-04 | — | — | US | disclosed |
| US-20030166279-A1 | Cell culture incubation and transferring nucleic acid from a minicell to a cell; diagnositic and therapeutic uses, as research tools and agents for drug discovery screening | MPEX BIOSCIENCES, INC. | 2003-09-04 | — | — | US | disclosed |
| WO-2003072014-A2 | MINICELL COMPOSITIONS AND METHODS | MPEX BIOSCIENCE, INC. (US) | 2003-09-04 | — | — | WO | disclosed |
| WO-2002094867-A2 | SEQUENCE OF THE PHOTORHABDUS LUMINESCENS STRAIN TT01 GENOME AND USES | INSTITUT PASTEUR (FR) | 2002-11-28 | — | — | WO | disclosed |