Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 12/20 | 0.40 |
| ▸ | CA2 | P00918 | 12/20 | 0.40 |
| ▸ | CA12 | O43570 | 11/20 | 0.40 |
| ▸ | CA6 | P23280 | 11/20 | 0.40 |
| ▸ | CA7 | P43166 | 11/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzthiazide SCHEMBL2449654 | 1.00 | ALDH1A1 (0.51) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL198231 | 0.90 | ALDH1A1 (0.52) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL936396 | 0.89 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL26257 | 0.88 | ALDH1A1 (0.63) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL2376967 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL1276519 | 0.87 | ALDH1A1 (0.60) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL9517821 | 0.87 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL345215 | 0.87 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL7217920 | 0.87 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL7102453 | 0.87 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697531-B1 | PROCESS FOR PREPARING L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY | EVONIK DEGUSSA GMBH (DE) | 2016-05-18 | — | — | EP | claimed |
| EP-1611245-B1 | PROCESS FOR THE PRODUCTION OF L-THREONINE USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY WHICH CONTAIN AN ENHANCE YFIDD ORF AND/OR PFLD GENE | EVONIK DEGUSSA GMBH (DE) | 2015-09-09 | — | — | EP | claimed |
| EP-1706482-B1 | PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY | EVONIK DEGUSSA GMBH (DE) | 2015-07-22 | — | — | EP | claimed |
| EP-1776451-B1 | METHOD FOR THE PRODUCTION OF L-AMINO ACIDS USING STRAINS FROM THE ENTEROBACTERACEAE FAMILY | EVONIK DEGUSSA GMBH (DE) | 2011-09-14 | — | — | EP | claimed |
| EP-1483392-B1 | PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE FAMILY ENTEROBACTERIACEAE | EVONIK DEGUSSA GMBH (DE) | 2010-12-01 | — | — | EP | claimed |
| EP-1697530-B1 | PROCESS FOR PREPARING L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY | EVONIK DEGUSSA GMBH (DE) | 2010-03-31 | — | — | EP | claimed |
| EP-1608764-B1 | A PROCESS FOR THE PRODUCTION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY WHICH OVEREXPRESS THE GALP GENE, CODING FOR A GALACTOSE PROTON SYMPORTER | EVONIK DEGUSSA GMBH (DE) | 2007-12-26 | — | — | EP | claimed |