Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15337706 | 0.76 | LRRK2 (0.41) | TBK1JAK2 | |
| SCHEMBL19527712 | 0.76 | LRRK2 (0.41) | TBK1JAK2 | |
| SCHEMBL18061447 | 0.76 | LRRK2 (0.41) | TBK1JAK2 | |
| SCHEMBL15337276 | 0.76 | LRRK2 (0.41) | TBK1JAK2 | |
| SCHEMBL17694844 | 0.73 | TBK1 (0.39) | TBK1JAK2 | |
| SCHEMBL17708412 | 0.68 | SYK (0.51) | TBK1JAK2 | |
| SCHEMBL18994970 | 0.66 | DYRK1A (0.39) | TBK1JAK2 | |
| SCHEMBL17708040 | 0.66 | DYRK1A (0.39) | TBK1JAK2 | |
| SCHEMBL15337709 | 0.66 | LRRK2 (0.38) | TBK1JAK2 | |
| SCHEMBL15337484 | 0.66 | LRRK2 (0.38) | TBK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005777-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20180030050-A1 | Protein Kinase C Inhibitors and Uses Thereof | MIDCAP FINANCIAL TRUST | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005777-B2 | Protein kinase C inhibitors and uses thereof | PRKCH, PRKCA, PRKCB | TBK1 130/4885JAK2 335/4885TSHR 3710/4885 |
| US-20180030050-A1 | Protein Kinase C Inhibitors and Uses Thereof | PRKCH, PRKCA, PRKCB | TBK1 130/4885JAK2 335/4885TSHR 3710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.