Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 8/20 | 0.34 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19840986 | 0.83 | LIMK1 (0.31) | — | |
| SCHEMBL19840799 | 0.81 | HDAC3 (0.46) | CD274HDAC1 | |
| SCHEMBL19841018 | 0.81 | FPR3 (0.33) | — | |
| SCHEMBL19840778 | 0.79 | HDAC1 (0.36) | PDCD1CD274HDAC1 | |
| SCHEMBL19840954 | 0.79 | — | — | |
| SCHEMBL19841088 | 0.77 | PDE10A (0.42) | — | |
| SCHEMBL19841003 | 0.77 | SMN1; SMN2 (0.44) | HDAC1 | |
| SCHEMBL19840787 | 0.76 | MEN1 (0.47) | HDAC1 | |
| SCHEMBL19841095 | 0.75 | LMNA (0.32) | HDAC1 | |
| SCHEMBL19840881 | 0.75 | NTRK3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884832-B2 | Inhibitors targeting drug-resistant influenza A | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2018-02-06 | — | — | US | disclosed |