Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MYC | P01106 | 1/20 | 0.52 |
| ▸ | MAX | P61244 | 1/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15229768 | 0.86 | MYC (0.55) | POLBRAB9AMYCMAXPTGDR2 | |
| SCHEMBL6641665 | 0.83 | MYC (0.66) | POLBRAB9AMYCMAXPTGDR2 | |
| SCHEMBL7083803 | 0.81 | POLB (0.56) | POLBRAB9AMYCMAXPTGDR2 | |
| SCHEMBL6536346 | 0.75 | MYC (0.56) | POLBRAB9AMYCMAXCTSV | |
| SCHEMBL1989351 | 0.75 | SLC6A3 (0.56) | POLBMYCMAXLMNAMAPT | |
| SCHEMBL8382506 | 0.75 | POLB (0.64) | POLBRAB9AMYCMAXPTGDR2 | |
| SCHEMBL28207049 | 0.74 | PTGS2 (0.73) | POLBRAB9AMYCMAXPTGDR2 | |
| SCHEMBL6391559 | 0.74 | PTGS2 (0.69) | POLBRAB9AMYCMAXPTGDR2 | |
| SCHEMBL27607146 | 0.74 | BCAT2 (0.57) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30338973 | 0.74 | PTGDR2 (0.54) | POLBRAB9AMYCMAXPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2337784-A1 | MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-06-29 | — | — | EP | disclosed |
| WO-2010036871-A1 | MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-01 | — | — | WO | disclosed |