Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12601843 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL2008656 | 0.76 | KDM4E (0.45) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL1987583 | 0.68 | HSD17B10 (0.45) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL1983841 | 0.67 | KDM4E (0.42) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL17952747 | 0.64 | KDM4E (0.46) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL24282265 | 0.63 | KDM4E (0.56) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL11047658 | 0.63 | ALDH1A1 (0.81) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL24305497 | 0.62 | BCHE (0.42) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL904332 | 0.62 | SLC6A2 (0.46) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL2293889 | 0.62 | MAOA (0.39) | KDM4EALDH1A1HPGDHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9303037-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-05 | — | — | US | disclosed |
| US-20140066479-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-06 | — | — | US | disclosed |
| US-8580840-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-11-12 | — | — | US | disclosed |
| US-8318766-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-11-27 | — | — | US | disclosed |
| EP-1907394-B1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-29 | — | — | EP | disclosed |
| US-20100210658-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | SUI ZHIHUA | 2010-08-19 | — | — | US | disclosed |
| US-20100204239-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | SUI ZHIHUA | 2010-08-12 | — | — | US | disclosed |
| US-7759498-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V (BE) | 2010-07-20 | — | — | US | disclosed |
| US-7696239-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-13 | — | — | US | disclosed |
| US-20080114048-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | SUI ZHIHUA | 2008-05-15 | — | — | US | disclosed |
| US-7338973-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-04 | — | — | US | disclosed |
| US-20060116513-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
| US-20060116415-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116415-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | NR5A1, ESRRA, SHBG | KDM4E 3631/4885ALDH1A1 3609/4885HPGD 1459/4885 |
| US-20100204239-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | NR5A1, ESRRA, SHBG | KDM4E 3631/4885ALDH1A1 3609/4885HPGD 1459/4885 |
| US-20060116513-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | NR5A1, ESRRA, SHBG | KDM4E 3631/4885ALDH1A1 3609/4885HPGD 1459/4885 |
| US-20140066479-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | NR5A1, ESRRA, SHBG | KDM4E 3631/4885ALDH1A1 3609/4885HPGD 1459/4885 |
| US-20080114048-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | NR5A1, ESRRA, SHBG | KDM4E 3631/4885ALDH1A1 3609/4885HPGD 1459/4885 |
| US-20100210658-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | NR5A1, ESRRA, SHBG | KDM4E 3631/4885ALDH1A1 3609/4885HPGD 1459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.