Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.56 |
| ▸ | CTSS | P25774 | 5/20 | 0.56 |
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.40 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19619076 | 1.00 | CTSK (0.56) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL13305464 | 0.85 | CTSK (0.54) | CTSKCTSSCTSLCTSBGAA | |
| SCHEMBL8307743 | 0.82 | CTSK (0.44) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL16492888 | 0.80 | KMT2A (0.44) | CTSKCTSSCTSLCTSBGAA | |
| SCHEMBL16119294 | 0.80 | CTSK (0.61) | CTSKCTSSCTSLCTSBAAK1 | |
| SCHEMBL14225360 | 0.77 | CTSK (0.61) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL17559 | 0.77 | CTSL (0.66) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL66243 | 0.77 | CTSL (0.66) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL21675512 | 0.77 | CTSK (0.61) | CTSKCTSSCTSLCTSBCAPN1 | |
| SCHEMBL7433744 | 0.77 | CTSK (0.61) | CTSKCTSSCTSLCTSBCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018024645-A1 | PROCESS FOR MAKING CARFILZOMIB | SYNTHON B.V. (NL) | 2018-02-08 | — | — | WO | disclosed |