SCHEMBL66243

SCHEMBL66243

CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CTSL P07711 2/20 0.66
CTSS P25774 2/20 0.66
CTSK P43235 2/20 0.66
CTSB P07858 1/20 0.66
CAPN1 P07384 1/20 0.57
ALDH1A1 P00352 2/20 0.56
MEN1 O00255 1/20 0.53
LMNA P02545 1/20 0.53
KMT2A Q03164 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA7 P43166 1/20 0.53
FOLH1 Q04609 5/20 0.53
MAPT P10636 1/20 0.50
LAP3 P28838 3/20 0.49
MAPK1 P28482 1/20 0.48
AAK1 Q2M2I8 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17559 1.00 CTSL (0.66) CTSLCTSSCTSKCTSBCAPN1
SCHEMBL17560 1.00 CTSL (0.66) CTSLCTSSCTSKCTSBCAPN1
Fluoride SCHEMBL27561259 0.98 CTSL (0.64) CTSLCTSSCTSKCTSBCAPN1
Water SCHEMBL11331808 0.98 CTSS (0.68) CTSLCTSSCTSKCTSBCAPN1
Water SCHEMBL1069558 0.98 CTSS (0.68) CTSLCTSSCTSKCTSBCAPN1
Water SCHEMBL645995 0.98 CTSS (0.68) CTSLCTSSCTSKCTSBCAPN1
SCHEMBL28058660 0.98 CTSL (0.64) CTSLCTSSCTSKCTSBCAPN1
SCHEMBL8579795 0.98 CTSL (0.64) CTSLCTSSCTSKCTSBCAPN1
Water SCHEMBL2838131 0.98 CTSS (0.68) CTSLCTSSCTSKCTSBCAPN1
Hydrazine SCHEMBL8410651 0.97 CTSL (0.62) CTSLCTSSCTSKCTSBCAPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 366 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120192379-A Marine cyclic peptide and synthesis method and application thereof 内蒙古大学 2025-06-24 CN claimed
CN-120136948-A Cycloastragal derivative with activity of resisting methicillin-resistant staphylococcus aureus and preparation method thereof 山西医科大学 2025-06-13 CN claimed
US-20250100999-A1 METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2025-03-27 US claimed
WO-2025019172-A1 ANTIMICROBIAL EXTRACTANT FORMED FROM COPPER-CONTAINING SOURCE CORNING INCORPORATED (US) 2025-01-23 WO claimed
WO-2024017221-A1 SYNTHESIS METHOD FOR α-AZIDO KETONE CONTAINING TERTIARY STEREOCENTER 常州大学 2024-01-25 WO claimed
EP-4253366-A2 METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION Gilead Sciences, Inc. (US) 2023-10-04 EP claimed
US-11760746-B2 Methods and intermediates for preparing therapeutic compounds GILEAD SCIENCES, INC. (US) 2023-09-19 US claimed
CN-115108937-B Synthesis method of alpha-azido ketone containing three-level stereo center 常州大学 2023-08-22 CN claimed
CN-112055712-B Methods and intermediates for preparing therapeutic compounds useful in the treatment of retroviral infections 吉利德科学公司 2023-07-14 CN claimed
EP-3752496-B1 METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION GILEAD SCIENCES INC (US) 2023-07-05 EP claimed
CN-116023347-A Method for preparing carfilzomib side chain isomer 无锡紫杉药业股份有限公司 2023-04-28 CN claimed
CN-115368352-A Glucokinase agonist and preparation method and application thereof 南京盛德瑞尔医药科技有限公司 2022-11-22 CN claimed
CN-115108937-A Synthesis method of alpha-azidoketone containing three-level stereocenter 常州大学 2022-09-27 CN claimed
CN-109438363-B Liquid-phase high-purity large-scale synthesis method of cyclic (leucyl-arginyl) dipeptide salt 陕西慧康生物科技有限责任公司 2022-04-29 CN claimed
EP-3988538-A1 MODIFIED HYDROPHOBIC AUXILIARY MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF Zhejiang Zhida Pharmaceutical Co., Ltd. (CN) 2022-04-27 EP claimed
US-20220111055-A1 MODIFIED HYDROPHOBIC EXCIPIENT AND PREPARATION METHOD THEREOF ZHEJIANG ZHIDA PHARMACEUTICAL CO., LTD. (CN) 2022-04-14 US claimed
CN-114195741-A Preparation method of carfilzomib key intermediate isomer 南京格亚医药科技有限公司 2022-03-18 CN claimed
WO-2020252713-A1 MODIFIED HYDROPHOBIC AUXILIARY MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF 浙江智达药业有限公司 2020-12-24 WO claimed
CN-112110834-A Modified hydrophobic auxiliary material and preparation method and application thereof 浙江智达药业有限公司 2020-12-22 CN claimed
CN-116854630-B Methods and intermediates for preparing therapeutic compounds useful in the treatment of retroviral infections 吉利德科学公司 2026-05-19 CN disclosed
US-12616676-B2 Preparation method and use of modified hydrophobic excipient ZHEJIANG ZHIDA PHARMACEUTICAL CO., LTD. (CN) 2026-05-05 US disclosed
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-04-02 US disclosed
US-20260041673-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-02-12 US disclosed
US-12472165-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-11-18 US disclosed
US-20250332148-A1 RILUZOLE PRODRUGS AND THEIR USE BIOHAVEN THERAPEUTICS LTD (US) 2025-10-30 US disclosed
US-20250281424-A1 SMALL MOLECULE ANTAGONISTS OF PF4 ZHOU YUHANG (US) 2025-09-11 US disclosed
EP-4613745-A2 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND Gilead Sciences, Inc. (US) 2025-09-10 EP disclosed
US-20250268979-A1 COMBINATION OF MACROCYCLIC CFTR MODULATORS WITH CFTR CORRECTORS AND / OR CFTR POTENTIATORS IDORSIA PHARMACEUTICALS LTD (CH) 2025-08-28 US disclosed
US-20250269043-A1 TARGETED BIFUNCTIONAL DEGRADERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2025-08-28 US disclosed
US-20250243196-A1 CITRON KINASE INHIBITORS THE CLEVELAND CLINIC FOUNDATION 2025-07-31 US disclosed
US-12365666-B2 Process for preparing a Cot inhibitor compound GILEAD SCIENCES, INC. (US) 2025-07-22 US disclosed
CN-120192379-A Marine cyclic peptide and synthesis method and application thereof 内蒙古大学 2025-06-24 CN disclosed
CN-120136948-A Cycloastragal derivative with activity of resisting methicillin-resistant staphylococcus aureus and preparation method thereof 山西医科大学 2025-06-13 CN disclosed
US-20250179118-A1 NOVEL DIPEPTIDE COMPOUNDS AND USES THEREOF SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES, LTD. (CN) 2025-06-05 US disclosed
CN-120058576-A Pleuromutilin derivative with amino acid fragment, and preparation method and application thereof 中国医学科学院药物研究所 2025-05-30 CN disclosed
EP-4126862-B1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND GILEAD SCIENCES INC (US) 2025-05-21 EP disclosed
US-12295942-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-05-13 US disclosed
US-20250100999-A1 METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2025-03-27 US disclosed
CN-116874515-B Amino acid-BSH targeted hybrid compound, and preparation method and application thereof 重庆高硼生物科技有限公司 2025-03-14 CN disclosed
CN-119613312-A With C2Chiral primary amine catalyst with axisymmetric structure, and preparation method and application thereof 石河子大学 2025-03-14 CN disclosed
CN-114163437-B Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors 阿雷生物药品公司 2025-03-04 CN disclosed
EP-3873916-B1 NOVEL DIPEPTIDE COMPOUNDS AND USES THEREOF SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO LTD (CN) 2025-02-19 EP disclosed
CN-119390681-A Process for preparing COT inhibitor compounds 吉利德科学公司 2025-02-07 CN disclosed
US-12215100-B2 Anticancer compounds PHARMA MAR, S.A. (ES) 2025-02-04 US disclosed
US-12213965-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-02-04 US disclosed
US-12209141-B2 Dipeptide compounds and uses thereof SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES, LTD. (CN) 2025-01-28 US disclosed
WO-2025019172-A1 ANTIMICROBIAL EXTRACTANT FORMED FROM COPPER-CONTAINING SOURCE CORNING INCORPORATED (US) 2025-01-23 WO disclosed
EP-4493221-A2 TARGETED BIFUNCTIONAL DEGRADERS Yale University (US) 2025-01-22 EP disclosed
CN-119212727-A Targeted bifunctional degradants 耶鲁大学 2024-12-27 CN disclosed
CN-113195515-B Novel dipeptide compounds and use thereof 丽珠医药集团股份有限公司 2024-11-15 CN disclosed
US-12122765-B2 Methods and intermediates for preparing therapeutic compounds GILEAD SCIENCES, INC. (US) 2024-10-22 US disclosed
CN-115397824-B Process for preparing COT inhibitor compounds 吉利德科学公司 2024-10-22 CN disclosed
EP-3988538-B1 MODIFIED HYDROPHOBIC AUXILIARY MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF ZHEJIANG ZHIDA PHARMACEUTICAL CO LTD (CN) 2024-08-07 EP disclosed
US-20240208992-A1 MACROCYCLES AS CFTR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2024-06-27 US disclosed
US-20240199579-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND GILEAD SCIENCES, INC. 2024-06-20 US disclosed
US-12005046-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 US disclosed
US-12005047-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 US disclosed
US-11981660-B2 Neurite outgrowth promoters and uses thereof UNIVERSITY OF MIAMI (US) 2024-05-14 US disclosed
CN-116813691-B Novel dipeptide compounds and use thereof 丽珠医药集团股份有限公司 2024-04-12 CN disclosed
US-20240101533-A1 METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2024-03-28 US disclosed
CN-116041361-B Amino acid derivative of parthenolide, and preparation method and application thereof 山东第一医科大学(山东省医学科学院) 2024-03-26 CN disclosed
US-20240091205-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2024-03-21 US disclosed
US-11932628-B2 Selective small molecule peptidomimetic melanocortin ligands REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2024-03-19 US disclosed
US-11911369-B2 Prodrugs of riluzole and their method of use BIOHAVEN THERAPEUTICS LTD. (VG) 2024-02-27 US disclosed
WO-2024032852-A1 CYCLOACETAMIDE, NOVEL NATURAL PRODUCT FROM MORTIERELLA ALPINA, PROCESS FOR PRODUCTION THEREOF, USE THEREOF AND MORTIERELLA ALPINA DSM 34346 FRIEDRICH-SCHILLER-UNIVERSITÄT JENA (DE) 2024-02-15 WO disclosed
CN-116496288-B Amine derivative protected by parthenolide Boc and preparation method and application thereof 山东第一医科大学(山东省医学科学院) 2024-01-26 CN disclosed
WO-2024017221-A1 SYNTHESIS METHOD FOR α-AZIDO KETONE CONTAINING TERTIARY STEREOCENTER 常州大学 2024-01-25 WO disclosed
US-20240018161-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2024-01-18 US disclosed
US-20240018161-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2024-01-18 US disclosed
US-20240018161-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2024-01-18 US disclosed
US-11845737-B2 Process for preparing a Cot inhibitor compound GILEAD SCIENCES, INC. (US) 2023-12-19 US disclosed
EP-3612532-B1 VMAT2 INHIBITOR COMPOUNDS AND COMPOSITIONS THEREOF NEUROCRINE BIOSCIENCES INC (US) 2023-12-13 EP disclosed
US-20230381150-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2023-11-30 US disclosed
US-20230381149-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2023-11-30 US disclosed
US-20230365587-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS (SAN DIEGO) LLC 2023-11-16 US disclosed
US-20230365587-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS (SAN DIEGO) LLC 2023-11-16 US disclosed
CN-109641863-B Intermediate for synthesizing carfilzomib and synthesis of pharmaceutically acceptable salt thereof 美国安进公司 2023-10-20 CN disclosed
CN-116874515-A Amino acid-BSH targeted hybrid compound, and preparation method and application thereof 重庆高硼生物科技有限公司 2023-10-13 CN disclosed
CN-116854630-A Methods and intermediates for preparing therapeutic compounds useful in the treatment of retroviral infections 吉利德科学公司 2023-10-10 CN disclosed
EP-4253366-A2 METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION Gilead Sciences, Inc. (US) 2023-10-04 EP disclosed
CN-116813691-A Novel dipeptide compounds and use thereof 丽珠医药集团股份有限公司 2023-09-29 CN disclosed
WO-2023178199-A2 TARGETED BIFUNCTIONAL DEGRADERS YALE UNIVERSITY (US) 2023-09-21 WO disclosed
CN-116670143-A Modulators of cystic fibrosis transmembrane conductance regulator 弗特克斯药品有限公司 2023-08-29 CN disclosed
CN-115108937-B Synthesis method of alpha-azido ketone containing three-level stereo center 常州大学 2023-08-22 CN disclosed
EP-4225447-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2023-08-16 EP disclosed
CN-115368352-B Glucokinase agonist and preparation method and application thereof 南京盛德瑞尔医药科技有限公司 2023-08-15 CN disclosed
EP-3898613-B1 ANTICANCER COMPOUNDS PHARMA MAR SA (ES) 2023-08-09 EP disclosed
CN-116496288-A Amine derivative protected by parthenolide Boc and preparation method and application thereof 山东第一医科大学(山东省医学科学院) 2023-07-28 CN disclosed
US-11708341-B2 Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof AMGEN INC. 2023-07-25 US disclosed
US-11708341-B2 Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof AMGEN INC. 2023-07-25 US disclosed
CN-112055712-B Methods and intermediates for preparing therapeutic compounds useful in the treatment of retroviral infections 吉利德科学公司 2023-07-14 CN disclosed
EP-3752496-B1 METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION GILEAD SCIENCES INC (US) 2023-07-05 EP disclosed
WO-2023078410-A1 COMPOUND HAVING ACTIVITY OF DEGRADING GSPT1 AND APPLICATION THEREOF 上海美志医药科技有限公司 2023-05-11 WO disclosed
CN-116041361-A Amino acid derivative of parthenolide, and preparation method and application thereof 山东第一医科大学(山东省医学科学院) 2023-05-02 CN disclosed
CN-116023347-A Method for preparing carfilzomib side chain isomer 无锡紫杉药业股份有限公司 2023-04-28 CN disclosed
CN-116023347-A Method for preparing carfilzomib side chain isomer 无锡紫杉药业股份有限公司 2023-04-28 CN disclosed
CN-115925615-A Preparation method of optically pure 2-methylpiperidine-5-amine 甘肃皓天医药科技有限责任公司 2023-04-07 CN disclosed
CN-110770236-B VMAT2 inhibitor compounds and compositions thereof 纽罗克里生物科学有限公司 2023-03-24 CN disclosed
US-20230087994-A1 TARGETED BIFUNCTIONAL DEGRADERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2023-03-23 US disclosed
EP-3727378-B1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA MERCK SHARP & DOHME LLC (US) 2023-02-22 EP disclosed
US-11583538-B2 Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors Venenum Biodesign, LLC (US) 2023-02-21 US disclosed
EP-4126862-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND GILEAD SCIENCES, INC. (US) 2023-02-08 EP disclosed
US-20230017637-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2023-01-19 US disclosed
US-20220396555-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD. (US) 2022-12-15 US disclosed
US-20220388947-A1 Nitrogen-containing Derivative of Substituted Phenol Hydroxy Acid Ester, and Preparation and Use Thereof WEST CHINA HOSPITAL, SICHUAN UNIVERSITY (CN) 2022-12-08 US disclosed
US-20220380340-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND GILEAD SCIENCES, INC. 2022-12-01 US disclosed
CN-115368352-A Glucokinase agonist and preparation method and application thereof 南京盛德瑞尔医药科技有限公司 2022-11-22 CN disclosed
CN-115315272-A Targeting difunctional degradation agent 耶鲁大学 2022-11-08 CN disclosed
CN-112110834-B Modified hydrophobic auxiliary material and preparation method and application thereof 浙江智达药业有限公司 2022-10-21 CN disclosed
WO-2022216717-A1 CITRON KINASE INHIBITORS THE CLEVELAND CLINIC FOUNDATION (US) 2022-10-13 WO disclosed
US-20220326230-A1 NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF FIRMENICH INCORPORATED (US) 2022-10-13 US disclosed
CN-115108937-A Synthesis method of alpha-azidoketone containing three-level stereocenter 常州大学 2022-09-27 CN disclosed
EP-4041262-A1 TARGETED BIFUNCTIONAL DEGRADERS Yale University (US) 2022-08-17 EP disclosed
US-20220213068-A1 SELECTIVE SMALL MOLECULE PEPTIDOMIMETIC MELANOCORTIN LIGANDS TORREY PINES INSTITUTE FOR MOLECULAR STUDIES 2022-07-07 US disclosed
US-20220213111-A1 SUBSTITUTED HETEROCYCLES AS CYCLIC TREX1 INHIBITORS Venenum Biodesign, LLC (US) 2022-07-07 US disclosed
EP-4011870-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING RILUZOLE PRODRUGS Biohaven Pharmaceutical Holding Company Ltd. (US) 2022-06-15 EP disclosed
US-20220177471-A1 N-1 BRANCHED ALKYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2022-06-09 US disclosed
CN-109438363-B Liquid-phase high-purity large-scale synthesis method of cyclic (leucyl-arginyl) dipeptide salt 陕西慧康生物科技有限责任公司 2022-04-29 CN disclosed
EP-3988538-A1 MODIFIED HYDROPHOBIC AUXILIARY MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF Zhejiang Zhida Pharmaceutical Co., Ltd. (CN) 2022-04-27 EP disclosed
CN-110267960-B Substituted pyrazolo [1,5-a ] pyrazine compounds as RET kinase inhibitors 阿雷生物药品公司 2022-04-26 CN disclosed
US-11306098-B2 Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors Venenum Biodesign, LLC (US) 2022-04-19 US disclosed
WO-2022076625-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed
WO-2022076625-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed
WO-2022075974-A1 CYCLIC TREX1 INHIBITORS Venenum Biodesign, LLC (US) 2022-04-14 WO disclosed
US-20220110909-A1 PREPARATION METHOD AND USE OF MODIFIED HYDROPHOBIC EXCIPIENT ZHEJIANG ZHIDA PHARMACEUTICAL CO., LTD. (CN) 2022-04-14 US disclosed
US-20220111056-A1 DRUG-LOADED EMULSION ZHEJIANG ZHIDA PHARMACEUTICAL CO., LTD. (CN) 2022-04-14 US disclosed
US-20220111055-A1 MODIFIED HYDROPHOBIC EXCIPIENT AND PREPARATION METHOD THEREOF ZHEJIANG ZHIDA PHARMACEUTICAL CO., LTD. (CN) 2022-04-14 US disclosed
EP-3980415-A1 N-1 BRANCHED ALKYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS 3M Innovative Properties Company (US) 2022-04-13 EP disclosed
WO-2022073003-A1 SMALL MOLECULE ANTAGONISTS OF PF4 NEW YORK BLOOD CENTER, INC (US) 2022-04-07 WO disclosed
CN-114195741-A Preparation method of carfilzomib key intermediate isomer 南京格亚医药科技有限公司 2022-03-18 CN disclosed
CN-114195741-A Preparation method of carfilzomib key intermediate isomer 南京格亚医药科技有限公司 2022-03-18 CN disclosed
US-11268952-B2 Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof FIRMENICH INCORPORATED (US) 2022-03-08 US disclosed
US-20220056021-A1 ANTICANCER COMPOUNDS PHARMA MAR, S.A. (ES) 2022-02-24 US disclosed
EP-3953333-A1 NOVEL CYCLIC TREX1 INHIBITORS Venenum Biodesign, LLC (US) 2022-02-16 EP disclosed
US-20210395299-A1 NOVEL DIPEPTIDE COMPOUNDS AND USES THEREOF SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES, LTD. (CN) 2021-12-23 US disclosed
US-11179389-B2 Purine inhibitors of human phosphatidylinositol 3-kinase delta MERCK SHARP & DOHME CORP. (US) 2021-11-23 US disclosed
US-11179389-B2 Purine inhibitors of human phosphatidylinositol 3-kinase delta MERCK SHARP & DOHME CORP. (US) 2021-11-23 US disclosed
EP-3873916-A1 NOVEL DIPEPTIDE COMPOUNDS AND USES THEREOF Huahai US Inc. (US) 2021-09-08 EP disclosed
US-20210236470-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD. 2021-08-05 US disclosed
US-20210236471-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2021-08-05 US disclosed
CN-113195515-A Novel dipeptides and uses thereof 华海美国公司 2021-07-30 CN disclosed
US-20210228549-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2021-07-29 US disclosed
EP-3297678-B1 AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF LAURUS LABS LTD (IN) 2021-07-07 EP disclosed
US-11052070-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2021-07-06 US disclosed
CN-107567438-B Riluzole prodrugs and uses thereof 拜尔哈文制药股份有限公司 2021-06-29 CN disclosed
US-11040970-B2 VMAT2 inhibitor compounds and compositions thereof NEUROCRINE BIOSCIENCES, INC. (US) 2021-06-22 US disclosed
WO-2021078073-A1 N-CONTAINING DERIVATIVE OF SUBSTITUTED PHENOL HYDROXY ACID ESTER, AND PREPARATION AND USE THEREOF 四川大学华西医院 2021-04-29 WO disclosed
CN-109553633-B Preparation method of phenylacetic acid type aryne 湖北大学 2021-03-19 CN disclosed
US-10905681-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2021-02-02 US disclosed
WO-2020252713-A1 MODIFIED HYDROPHOBIC AUXILIARY MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF 浙江智达药业有限公司 2020-12-24 WO disclosed
CN-112110834-A Modified hydrophobic auxiliary material and preparation method and application thereof 浙江智达药业有限公司 2020-12-22 CN disclosed
US-20200390760-A1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA MERCK SHARP & DOHME CORP. (US) 2020-12-17 US disclosed
US-20200390760-A1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA MERCK SHARP & DOHME CORP. (US) 2020-12-17 US disclosed
WO-2020245706-A1 N-1 BRANCHED ALKYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS 3M INNOVATIVE PROPERTIES COMPANY (US) 2020-12-10 WO disclosed
EP-3494108-B1 SYNTHESIS OF (S)-2-AMINO-4-METHYL-1-((R)-2-METHYLOXIRANE-2-YL)-PENTAN-1-ONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AMGEN INC (US) 2020-10-28 EP disclosed
US-10800809-B2 Processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof LAURUS LABS LIMITED (IN) 2020-10-13 US disclosed
US-20200289475-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2020-09-17 US disclosed
EP-3478662-B1 AZADECALIN DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION VIIV HEALTHCARE UK (NO5) LTD (GB) 2020-09-16 EP disclosed
US-10639298-B2 Prodrugs of riluzole and their method of use BIOHAVEN THERAPEUTICS LTD. (US) 2020-05-05 US disclosed
US-20200131173-A1 VMAT2 INHIBITOR COMPOUNDS AND COMPOSITIONS THEREOF NEUROCRINE BIOSCIENCES, INC. 2020-04-30 US disclosed
US-20200085794-A1 RILUZOLE PRODRUGS AND THEIR USE BIOHAVEN THERAPEUTICS LTD. (JP) 2020-03-19 US disclosed
EP-3612532-A1 VMAT2 INHIBITOR COMPOUNDS AND COMPOSITIONS THEREOF Neurocrine Biosciences, Inc. (US) 2020-02-26 EP disclosed
CN-110770236-A VMAT2 inhibitor compounds and compositions thereof 纽罗克里生物科学有限公司 2020-02-07 CN disclosed
US-20190292149-A1 ARYL SUBSTITUTED INDOLES AND THE USE THEREOF PURDUE PHARMA LP (US) 2019-09-26 US disclosed
US-20190284231-A1 PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF LAURUS LABS LIMITED (IN) 2019-09-19 US disclosed
US-10364269-B2 Processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof LAURUS LABS LIMITED (IN) 2019-07-30 US disclosed
EP-3466961-A1 PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF Li, Min (US) 2019-04-10 EP disclosed
US-10253027-B2 Aryl lactam kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2019-04-09 US disclosed
US-10242871-B2 Resist underlayer film-forming composition including a compound having an amino group protected with a tert-butoxycarbonyl group NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-03-26 US disclosed
US-20190085026-A1 AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Laurus Labs Ltd. (IN) 2019-03-21 US disclosed
US-10208023-B2 Heterocyclic inhibitors of the sodium channel DeGiacomo, Mark G. (US) 2019-02-19 US disclosed
WO-2018195121-A1 VMAT2 INHIBITOR COMPOUNDS AND COMPOSITIONS THEREOF NEUROCRINE BIOSCIENCES, INC. (US) 2018-10-25 WO disclosed
US-10035777-B2 Heterocyclic kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2018-07-31 US disclosed
CN-105517993-B Aryl amide kinase inhibitors 百时美施贵宝公司 2018-07-13 CN disclosed
EP-3054955-B1 PYRROLOTRIAZINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2018-05-30 EP disclosed
EP-2822559-B1 IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF LEXICON PHARMACEUTICALS INC (US) 2018-05-02 EP disclosed
CN-107935988-A Optionally substituted quinoline compounds 卫材R&D管理有限公司 2018-04-20 CN disclosed
EP-3057948-B1 SELECTIVELY SUBSTITUTED QUINOLINE DERIVATIVES EISAI R&D MAN CO LTD (JP) 2018-03-14 EP disclosed
EP-2928890-B1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARM SPA (IT) 2018-02-28 EP disclosed
US-20180036290-A1 RILUZOLE PRODRUGS AND THEIR USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2018-02-08 US disclosed
US-20180037557-A1 PRODRUGS RILUZOLE AND THEIR METHOD OF USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2018-02-08 US disclosed
WO-2018027021-A1 SYNTHESIS OF (S)-2-AMINO-4-METHYL-1-((R)-2-METHYLOXIRANE-2-YL)-PENTAN-1-ONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AMGEN INC. (US) 2018-02-08 WO disclosed
US-20180022699-A1 ARYL SUBSTITUTED INDOLES AND THE USE THEREOF PURDUE PHARMA L.P. 2018-01-25 US disclosed
CN-105636945-B Optionally substituted quinoline compounds 卫材R&D管理有限公司 2017-11-17 CN disclosed
US-20170283377-A1 ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-10-05 US disclosed
US-20170260145-A1 HETEROCYCLIC KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-09-14 US disclosed
US-20170250079-A1 RESIST UNDERLAYER FILM-FORMING COMPOSITION NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2017-08-31 US disclosed
US-20170250079-A1 RESIST UNDERLAYER FILM-FORMING COMPOSITION NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2017-08-31 US disclosed
CN-107108552-A Heterocyclic kinase inhibitors 百时美施贵宝公司 2017-08-29 CN disclosed
US-20170239249-A1 QUINAZOLINE-BASED KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-08-24 US disclosed
US-9737542-B2 Pyrrolotriazine kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2017-08-22 US disclosed
US-9708337-B2 Aryl amide-based kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2017-07-18 US disclosed
CN-104470523-B Compound based on imidazo [1,2 b] pyridazine, comprising their compositions and its application method 莱西肯医药有限公司 2017-07-11 CN disclosed
US-9682933-B2 Androgen receptor modulators and methods for their use BRITISH COLUMBIA CANCER AGENCY BRANCH (CA) 2017-06-20 US disclosed
US-9663486-B2 Selectively substituted quinoline compounds EISAI R&D MANAGEMENT CO., LTD. (JP) 2017-05-30 US disclosed
US-20170144969-A1 ANTIMICROBIAL CONJUGATES, METHOD FOR PRODUCTION AND USES THEREOF THE SECRETARY OF STATE FOR HEALTH (GB) 2017-05-25 US disclosed
US-20170144969-A1 ANTIMICROBIAL CONJUGATES, METHOD FOR PRODUCTION AND USES THEREOF THE SECRETARY OF STATE FOR HEALTH (GB) 2017-05-25 US disclosed
US-20170107203-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL EPIRUS BIOPHARMACEUTICALS, INC. (US) 2017-04-20 US disclosed
US-20170107203-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL EPIRUS BIOPHARMACEUTICALS, INC. (US) 2017-04-20 US disclosed
US-20170107203-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL EPIRUS BIOPHARMACEUTICALS, INC. (US) 2017-04-20 US disclosed
US-20170096454-A1 CYCLOHEPTAPEPTIDE AGENTS FOR TREATMENT OF CANCER AND OBESITY DISEASES HONG KONG BAPTIST UNIVERSITY (HK) 2017-04-06 US disclosed
US-20170057911-A1 SYNTHESIS OF ARYL CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS PROCTER & GAMBLE (US) 2017-03-02 US disclosed
US-20170057964-A1 IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE LEXICON PHARMACEUTICALS INC (US) 2017-03-02 US disclosed
EP-3110799-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL Epirus Biopharmaceuticals, Inc. (US) 2017-01-04 EP disclosed
EP-2958924-B1 5H-CHROMENO[3,4-C]PYRIDINES AS INHIBITORS OF ADAPTOR ASSOCIATED KINASE 1 (AAK1) BRISTOL MYERS SQUIBB CO (US) 2016-12-28 EP disclosed
WO-2016185450-A1 AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF LAURUS LABS PRIVATE LIMITED (IN) 2016-11-24 WO disclosed
US-20160326111-A1 ARYL SUBSTITUTED INDOLES AND THE USE THEREOF PURDUE PHARMA LP (US) 2016-11-10 US disclosed
US-9487479-B2 Small molecule inhibitors of N-terminus activation of the androgen receptor THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2016-11-08 US disclosed
US-9487479-B2 Small molecule inhibitors of N-terminus activation of the androgen receptor THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2016-11-08 US disclosed
CN-105979950-A Pyrrolotriazine kinase inhibitors 百时美施贵宝公司 2016-09-28 CN disclosed
US-9453013-B2 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity CHIESI FARMACEUTICI S.P.A. (IT) 2016-09-27 US disclosed
US-9453013-B2 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity CHIESI FARMACEUTICI S.P.A. (IT) 2016-09-27 US disclosed
US-9434760-B2 Prolinamide derivatives as thrombin inhibitors, preparation method and application thereof SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) 2016-09-06 US disclosed
US-20160243125-A1 PYRROLOTRIAZINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2016-08-25 US disclosed
EP-3057948-A1 SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS Eisai R&D Management Co., Ltd. (JP) 2016-08-24 EP disclosed
EP-2331501-B1 SMALL MOLECULE INHIBITORS OF N-TERMINUS ACTIVATION OF THE ANDROGEN RECEPTOR BRITISH COLUMBIA CANCER AGENCY (CA) 2016-07-20 EP disclosed
US-20160176841-A1 SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS EISAI R&D MANAGEMENT CO., LTD. (JP) 2016-06-23 US disclosed
US-20160152621-A1 ARYL LACTAM KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2016-06-02 US disclosed
CN-105636945-A Optionally substituted quinoline compounds EISAI R&D MAN CO LTD 2016-06-01 CN disclosed
EP-3019475-A1 ARYL AMIDE KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2016-05-18 EP disclosed
US-20160108049-A1 Novel Phthalazinone-Pyrrolopyrimidinecarboxamide Derivatives ASTRAZENECA AB (SE) 2016-04-21 US disclosed
CN-105517993-A Aryl amide kinase inhibitors BRISTOL MYERS SQUIBB CO 2016-04-20 CN disclosed
US-20160024093-A1 IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE LEXICON PHARMACEUTICALS INC (US) 2016-01-28 US disclosed
US-20160016967-A1 ARYL AMIDE-BASED KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2016-01-21 US disclosed
US-20160016939-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL NATIONAL CENTER FOR ADDICTION STUDIES AND TREATMENT FOUNDATION 2016-01-21 US disclosed
US-20160016939-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL NATIONAL CENTER FOR ADDICTION STUDIES AND TREATMENT FOUNDATION 2016-01-21 US disclosed
EP-2961403-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL Zalicus Pharmaceuticals Ltd. (US) 2016-01-06 EP disclosed
EP-2721030-B1 NOVEL PHTHALAZINONE-PYRROLOPYRIMIDINECARBOXAMIDE DERIVATIVES TAKEDA GMBH (DE) 2015-12-16 EP disclosed
US-9212139-B2 Aryl substituted indoles and their use as blockers of sodium channels PURDUE PHARMA, L.P. (US) 2015-12-15 US disclosed
US-20150344424-A1 ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE BRITISH COLUMBIA CANCER AGENCY BRANCH (CA) 2015-12-03 US disclosed
CN-105121445-A 5H-chromeno[3,4-c]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) BRISTOL MYERS SQUIBB CO 2015-12-02 CN disclosed
EP-2318361-B1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS NOVARTIS AG (CH) 2015-09-23 EP disclosed
EP-2318361-B1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS NOVARTIS AG (CH) 2015-09-23 EP disclosed
WO-2015127549-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL PAJOUHESH HASSAN (CA) 2015-09-03 WO disclosed
WO-2015127549-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL PAJOUHESH HASSAN (CA) 2015-09-03 WO disclosed
CN-102656179-B Bufalin derivatives, pharmaceutical compositions and uses thereof SUZHOU NEUPHARMA Co.,Ltd. (CN) 2015-07-29 CN disclosed
US-9062028-B2 Bicyclic nitrogen containing heteroaryl TGR5 receptor modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2015-06-23 US disclosed
US-20150139916-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARMACEUTICI S.P.A. (IT) 2015-05-21 US disclosed
US-9018197-B2 Tetradecahydro-1H-cyclopenta[a]phenanthrene compounds, compositions, and related methods of use SUZHOU NEUPHARMA CO. LTD. (CN) 2015-04-28 US disclosed
WO-2015057655-A1 SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS EISAI R&D MANAGEMENT CO., LTD. (JP) 2015-04-23 WO disclosed
EP-2440558-B1 DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK TAKEDA PHARMACEUTICAL (JP) 2015-04-01 EP disclosed
US-8980913-B2 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity CHIESI FARMACEUTICI S.P.A. (IT) 2015-03-17 US disclosed
US-8980913-B2 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity CHIESI FARMACEUTICI S.P.A. (IT) 2015-03-17 US disclosed
US-8969565-B2 Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use LEXICON PHARMACEUTICALS, INC. (US) 2015-03-03 US disclosed
WO-2015006100-A1 ARYL AMIDE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-01-15 WO disclosed
EP-2824097-A1 Prolinamide derivative as thrombin inhibitor, preparation method and application thereof Shanghai Institute of Pharmaceutical Industry (CN) 2015-01-14 EP disclosed
EP-2822559-A1 IMIDAZO [1, 2 - B]PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF Lexicon Pharmaceuticals, Inc. (US) 2015-01-14 EP disclosed
CN-102459267-B Dihydropyrrolonaphtyridinone compounds as inhibitors of JAK TAKEDA PHARMACEUTICAL 2014-11-26 CN disclosed
US-8895497-B2 Cathepsin S inhibitors DCB-USA, LLC (US) 2014-11-25 US disclosed
US-8841291-B2 Selective hydroxamic acid based MMP-12 and MMP-13 inhibitors NOVARTIS AG (CH) 2014-09-23 US disclosed
US-8841291-B2 Selective hydroxamic acid based MMP-12 and MMP-13 inhibitors NOVARTIS AG (CH) 2014-09-23 US disclosed
WO-2014134306-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL Zalicus Pharmaceuticals, Ltd. (US) 2014-09-04 WO disclosed
WO-2014134306-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL Zalicus Pharmaceuticals, Ltd. (US) 2014-09-04 WO disclosed
US-8785429-B2 Dihydropyrrolonaphthyridinone compounds as inhibitors of JAK TAKEDA PHARMACEUTICAL COMPANY LIMITED 2014-07-22 US disclosed
US-20140163066-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARMACEUTICI S.P.A. (IT) 2014-06-12 US disclosed
WO-2014086927-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARMACEUTICI S.P.A. (IT) 2014-06-12 WO disclosed
US-20140163066-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARMACEUTICI S.P.A. (IT) 2014-06-12 US disclosed
US-20140112945-A1 NOVEL PHTHALAZINONE-PYRROLOPYRIMIDINECARBOXAMIDE DERIVATIVES TAKEDA GMBH (DE) 2014-04-24 US disclosed
EP-2721030-A1 NOVEL PHTHALAZINONE-PYRROLOPYRIMIDINECARBOXAMIDE DERIVATIVES Takeda GmbH (DE) 2014-04-23 EP disclosed
US-20140080788-A1 NOVEL BICYCLIC NITROGEN CONTAINING HETEROARYL TGR5 RECEPTOR MODULATORS BRISTOL-MYERS SQUIBB COMPANY 2014-03-20 US disclosed
US-20140031399-A1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS NOVARTIS AG (CH) 2014-01-30 US disclosed
US-20140031399-A1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS NOVARTIS AG (CH) 2014-01-30 US disclosed
US-20130296245-A1 PROLINAMIADE DERIVATIVES AS THROMBIN INHIBITOR, PREPRARATION METHOD AND APPLICATION THEREOF SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) 2013-11-07 US disclosed
US-20130296281-A1 Aryl Substituted Indoles and Their Use as Blockers of Sodium Channels PURDUE PHARMA L.P. (US) 2013-11-07 US disclosed
US-20130245021-A1 IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE OXFORD FINANCE LLC, AS COLLATERAL AGENT 2013-09-19 US disclosed
EP-2639230-A1 PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF Shanghai Institute of Pharmaceutical Industry (CN) 2013-09-18 EP disclosed
WO-2013134219-A1 IMIDAZO [1, 2 - B] PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF LEXICON PHARMACEUTICALS, INC. (US) 2013-09-12 WO disclosed
US-8501772-B2 3,8-diaminotetrahydroquinoline derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 2013-08-06 US disclosed
US-8501772-B2 3,8-diaminotetrahydroquinoline derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 2013-08-06 US disclosed
US-20130190324-A1 TOPICAL OCULAR DRUG DELIVERY THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2013-07-25 US disclosed
US-20130184252-A1 DIHYDROPYRROLONAPHTHYRIDINONE COMPOUNDS AS INHIBITORS OF JAK TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-07-18 US disclosed
US-8420816-B2 Dihydropyrrolonaphthyridinone compounds as inhibitors of JAK TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-04-16 US disclosed
US-20130012537-A1 3,8-DIAMINOTETRAHYDROQUINOLINE DERIVATIVE ZERIA PHARMACEUTICAL CO., LTD. (JP) 2013-01-10 US disclosed
WO-2012171900-A1 NOVEL PHTHALAZINONE-PYRROLOPYRIMIDINECARBOXAMIDE DERIVATIVES NYCOMED GMBH (DE) 2012-12-20 WO disclosed
US-8299255-B2 3,8-diaminotetrahydroquinoline derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 2012-10-30 US disclosed
US-8236805-B2 Substituted piperazines as CB1 antagonists INTERVET INC. (US) 2012-08-07 US disclosed
CN-102464701-A Novel compound, preparation method and application thereof SHANGHAI INST PHARM INDUSTRY 2012-05-23 CN disclosed
CN-102459267-A Dihydropyrrolonaphtyridinone compounds as inhibitors of jak TAKEDA PHARMACEUTICAL 2012-05-16 CN disclosed
WO-2012027957-A1 BUFALIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF SUZHOU NEUPHARMA CO., LTD. (CN) 2012-03-08 WO disclosed
US-8129417-B2 Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers ABBOTT LABORATORIES (US) 2012-03-06 US disclosed
US-20120053162-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS SUZHOU NEUPHARMA CO. LTD. (CN) 2012-03-01 US disclosed
CN-102292319-A Novel substituted octahydrocyclopenta(C)pyrrol-4-amines as calcium channel blockers 2011-12-21 CN disclosed
WO-2011149995-A1 NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA [C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS ABBOTT LABORATORIES (US) 2011-12-01 WO disclosed
US-20110281870-A1 NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS ABBOTT LABORATORIES (US) 2011-11-17 US disclosed
EP-2367790-A2 SUBSTITUTED OCTAHYDROCYCLOPENTA(C)PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS Abbott Laboratories (US) 2011-09-28 EP disclosed
US-20110230539-A1 Small Molecule Inhibitors of N-Terminus Activation of the Androgen Receptor THE UNITED STATES GOVERNMENT 2011-09-22 US disclosed
US-20110230539-A1 Small Molecule Inhibitors of N-Terminus Activation of the Androgen Receptor THE UNITED STATES GOVERNMENT 2011-09-22 US disclosed
US-20110136780-A1 DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-09 US disclosed
WO-2011069149-A2 CATHEPSIN S INHIBITORS DCB-USA LLC (US) 2011-06-09 WO disclosed
US-20110112076-A1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS NOVARTIS AG (CH) 2011-05-12 US disclosed
US-20110112076-A1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS NOVARTIS AG (CH) 2011-05-12 US disclosed
EP-2318361-A1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS Novartis AG (CH) 2011-05-11 EP disclosed
US-20100317693-A1 3,8-DIAMINOTETRAHYDROQUINOLINE DERIVATIVE ZERIA PHARMACEUTICAL CO., LTD (JP) 2010-12-16 US disclosed
EP-2241564-A1 3,8-DIAMINOTETRAHYDROQUINOLINE DERIVATIVE Zeria Pharmaceutical Co., Ltd. (JP) 2010-10-20 EP disclosed
WO-2010062927-A2 NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA(C)PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS ABBOTT LABORATORIES (US) 2010-06-03 WO disclosed
US-20100130558-A1 NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS ABBOTT LABORATORIES (US) 2010-05-27 US disclosed
US-7700597-B2 Substituted piperazines as CB1 antagonists SCHERING CORPORATION (US) 2010-04-20 US disclosed
US-7700597-B2 Substituted piperazines as CB1 antagonists SCHERING CORPORATION (US) 2010-04-20 US disclosed
US-20100029607-A1 Substituted Piperazines as CB1 Antagonists SCHERING CORPORATION 2010-02-04 US disclosed
US-7651997-B2 Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2010-01-26 US disclosed
WO-2010007027-A1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS NOVARTIS AG (CH) 2010-01-21 WO disclosed
WO-2010007027-A1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS NOVARTIS AG (CH) 2010-01-21 WO disclosed
US-20100004250-A1 PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER CHROMA THERAPEUTICS LTD. (GB) 2010-01-07 US disclosed
US-20090306053-A1 Highly selective rho-kinase inhibitor D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) 2009-12-10 US disclosed
EP-1625153-B1 ACYLATED LYSOBACTIN-TYPE NONADEPSIPEPTIDES AICURIS GMBH & CO KG (DE) 2009-08-26 EP disclosed
US-7579346-B2 (R)-2-[(5-chlorothiophene-2-carbonyl)amino]-N-[3-methyl-4-(3-oxomorpholin-4-yl)phenyl]4-methylvaleramide, for example; inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors MERCK PATENT GMBH (DE) 2009-08-25 US disclosed
US-7579346-B2 (R)-2-[(5-chlorothiophene-2-carbonyl)amino]-N-[3-methyl-4-(3-oxomorpholin-4-yl)phenyl]4-methylvaleramide, for example; inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors MERCK PATENT GMBH (DE) 2009-08-25 US disclosed
WO-2009098901-A1 3,8-DIAMINOTETRAHYDROQUINOLINE DERIVATIVE ZERIA PHARMACEUTICAL CO., LTD. (JP) 2009-08-13 WO disclosed
EP-0976722-B1 BENZAMIDINE DERIVATIVES AJINOMOTO KK (JP) 2009-03-11 EP disclosed
EP-1878732-B1 HIGHLY SELECTIVE Rho-KINASE INHIBITOR WESTERN THERAPEUTICS INST INC (JP) 2009-02-25 EP disclosed
US-7396844-B1 Benzamidine derivatives AJINOMOTO CO., INC. (JP) 2008-07-08 US disclosed
US-7368424-B2 Acylated nonadepsipeptides AICURIS GMBH & CO. KG (DE) 2008-05-06 US disclosed
EP-1878732-A1 HIGHLY SELECTIVE Rho-KINASE INHIBITOR D. Western Therapeutics Institute (JP) 2008-01-16 EP disclosed
US-7285552-B2 Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient ONO PHARMACEUTICALS CO., LTD. (JP) 2007-10-23 US disclosed
EP-1338588-B1 METHOD OF RESOLVING OPTICAL ISOMERS OF AMINO ACID DERIVATIVE TOKUYAMA CORP (JP) 2007-09-26 EP disclosed
US-7265220-B2 Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative LES LABORATORIES SERVIER (FR) 2007-09-04 US disclosed
EP-1809657-A1 CYCLIC NONAPEPTIDE AMIDES AiCuris GmbH & Co. KG (DE) 2007-07-25 EP disclosed
US-7199264-B2 Method of resolving optical isomers of amino acid derivative TOKUYAMA CORPORATION (JP) 2007-04-03 US disclosed
US-7119091-B2 Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient ONO PHARMACEUTICAL CO., LTD. (JP) 2006-10-10 US disclosed
WO-2006048156-A1 CYCLIC NONAPEPTIDE AMIDES AICURIS GMBH & CO. KG (DE) 2006-05-11 WO disclosed
US-7037939-B2 Compound and derivative of gabapentin INDUSTRIAL TECHNOLOGY RESEARCH INSTITUE (TW) 2006-05-02 US disclosed
CN-1246321-C Triazaspiro [5,5] undecane derivatives and pharmaceutical compositions containing the same as active ingredient ONO PHARMACEUTICAL CO (JP) 2006-03-22 CN disclosed
EP-1625153-A1 ACYLATED LYSOBACTIN-TYPE NONADEPSIPEPTIDES Bayer HealthCare AG (DE) 2006-02-15 EP disclosed
US-20050085517-A1 Novel amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative LES LABORATOIRES SERVIER (FR) 2005-04-21 US disclosed
US-20050075281-A1 peptide antibiotics comprising lysobactin derivatives used for treatment and/or prophylaxis of bacterial infectious diseases; cyclic peptides BAYER HEALTHCARE AG (DE) 2005-04-07 US disclosed
US-20040248811-A1 Compound and derivative of gabapentin INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2004-12-09 US disclosed
EP-1236726-B1 TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO (JP) 2004-12-01 EP disclosed
WO-2004099239-A1 ACYLATED LYSOBACTIN-TYPE NONADEPSIPEPTIDES BAYER HEALTHCARE AG (DE) 2004-11-18 WO disclosed
EP-1476421-A2 NOVEL AMINO ACID DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVE LES LABORATOIRES SERVIER (FR) 2004-11-17 EP disclosed
CN-1533390-A Pharmaceutical composition comprising triazaspiro [5.5] undecane derivative as active ingredient СҰҩƷ��ҵ��ʽ���� 2004-09-29 CN disclosed
US-20040152740-A1 Arylglycine derivatives for use as glycine transport inhibitors NPS ALLELIX CORPORATION (CA) 2004-08-05 US disclosed
US-20040106619-A1 Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient ONO PHARMACEUTICALS CO., LTD. (JP) 2004-06-03 US disclosed
WO-2004046138-A1 CARBOXAMIDES MERCK PATENT GMBH (DE) 2004-06-03 WO disclosed
US-20040102646-A1 Method of resolving optical isomers of amino acid derivative TOKUYAMA CORPORATION (JP) 2004-05-27 US disclosed
US-20040097511-A1 Triazaspiro[5.5]undecane derivatives and drugs containing the same as the active ingredient PANASONIC CORPORATION (JP) 2004-05-20 US disclosed
WO-2004022534-A1 ARYLGLYCINE DERIVATIVES FOR USE AS GLYCINE TRANSPORT INHIBITORS NPS ALLELIX CORP. (CA) 2004-03-18 WO disclosed
CN-1473145-A Method for separating optical isomers of amino acid derivatives ��ʽ�����ɽ 2004-02-04 CN disclosed
EP-1378509-A1 DRUGS CONTAINING TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 2004-01-07 EP disclosed
CN-1130347-C Novel 2,3-methylene amino acid compound, prepn. method therefor, pharmaceutical compositions contg. same SOVIL LAB (FR) 2003-12-10 CN disclosed
WO-2003070690-A2 NOVEL AMINO ACID DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVE LES LABORATOIRES SERVIER (FR) 2003-08-28 WO disclosed
EP-1338588-A1 METHOD OF RESOLVING OPTICAL ISOMERS OF AMINO ACID DERIVATIVE TOKUYAMA CORPORATION (JP) 2003-08-27 EP disclosed
CN-1433419-A Triazaspiro [5,5] undecane derivatives and pharmaceutical compositions containing the same as active ingredient ONO PHARMACEUTICAL CO (JP) 2003-07-30 CN disclosed
EP-1236726-A1 TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 2002-09-04 EP disclosed
US-6399629-B1 PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY MICROCIDE PHARMACEUTICALS, INC. 2002-06-04 US disclosed
EP-1050534-B1 2,3-methano-amino acid derivatives, process for their preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2001-12-05 EP disclosed
US-6288077-B1 2-AZABICYCLO(3.1.0)HEXANE-1,2-DICARBOXYLIC AMIDE OR 2-AZABICYCLO(4.1.0)HEPTANE-1,2-DICARBOXYLIC AMIDE DERIVATIVE; TRYPSIN-LIKE SERINE PROTEASE INHIBITOR; ANTICOAGULANTS ADIR ET COMPAGNIE (FR) 2001-09-11 US disclosed
CN-1277961-A Novel 2,3-methylene amino acid compound, prepn. method therefor, pharmaceutical compositions contg. same ADIR (FR) 2000-12-27 CN disclosed
EP-1050534-A1 2,3-methano-amino acid derivatives, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 2000-11-08 EP disclosed
EP-0976722-A1 BENZAMIDINE DERIVATIVES Ajinomoto Co., Inc. (JP) 2000-02-02 EP disclosed
CN-1243505-A Benzamidine derivatives AJINOMOTO KK (JP) 2000-02-02 CN disclosed
WO-2000001714-A1 EFFLUX PUMP INHIBITORS MICROCIDE PHARMACEUTICALS, INC. (US) 2000-01-13 WO disclosed
EP-0717040-A1 Thiazine or thiazepine derivatives which inhibit NOS Japan Tobacco Inc. (JP) 1996-06-19 EP disclosed
CN-1124734-A Thiazine- or thiazepine-derivatives JAPAN TOBACCO INC (JP) 1996-06-19 CN disclosed
US-5494898-A DIQUATERNARY TRIPEPTIDES OHMEDA PHARMACEUTICAL PRODUCTS DIVISION INC. (US) 1996-02-27 US disclosed
US-5298409-A Of esters, antigen diastereomers which are stable analogs of the unstable ester transition states THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1994-03-29 US disclosed
US-5190865-A Antibody-enhanced stereospecific hydrolyses THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1993-03-02 US disclosed
EP-0498941-A2 Peptide skeletal muscle relaxants BOC Health Care, Inc. (US) 1992-08-19 EP disclosed
EP-0189803-B1 INDOL-3-YL-QUINAZOLINO-1,4-BENZODIAZEPIN-5,13-DIONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM MERCK & CO. INC. (US) 1990-04-25 EP disclosed
EP-0295316-A2 Antitumor amino acid and peptide derivatives of 1,4-bis[ (aminoalkyl and hydroxyaminoalkyl)- amino]-5,8 dihydroxyanthraquinones AMERICAN CYANAMID COMPANY (US) 1988-12-21 EP disclosed
US-4732970-A Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones AMERICAN CYANAMID COMPANY (US) 1988-03-22 US disclosed
EP-0189803-A1 Indol-3-yl-quinazolino-1,4-benzodiazepin-5,13-diones, process for their preparation and pharmaceutical compositions containing them MERCK & CO. INC. (US) 1986-08-06 EP disclosed
US-4559339-A CENTRAL NERVOUS SYSTEM, GASTROINTESTINAL DISORDERS MERCK & CO., INC. (US) 1985-12-17 US disclosed
US-4507232-A Peptide derivatives TAISHO PHARMACEUTICAL CO., LTD. (JP) 1985-03-26 US disclosed
EP-0113996-A2 Peptide derivatives TAISHO PHARMACEUTICAL CO. LTD (JP) 1984-07-25 EP disclosed
US-4228157-A Synthetic peptides having pituitary growth hormone releasing activity BECKMAN INSTRUMENTS, INC. (US) 1980-10-14 US disclosed
US-3971736-A HEXA- AND HEPTA-PEPTIDES, ANTIINFLAMMATORY, ANTIULCER, ANTIARTHRITIC MERCK & CO., INC. (US) 1976-07-27 US disclosed
US-3971736-A HEXA- AND HEPTA-PEPTIDES, ANTIINFLAMMATORY, ANTIULCER, ANTIARTHRITIC MERCK & CO., INC. (US) 1976-07-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (50 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140163066-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY ADRB2, ADRB1, ADRA2B CTSL 2974/4885CTSS 2939/4885CTSK 3003/4885
US-20160152621-A1 ARYL LACTAM KINASE INHIBITORS AAK1, ADCK1, ANKK1 CTSL 3992/4885CTSS 3931/4885CTSK 1026/4885
US-11845737-B2 Process for preparing a Cot inhibitor compound TPO, TFPI, TFPI2 CTSL 2655/4885CTSS 2588/4885CTSK 1838/4885
US-20230381150-A1 RILUZOLE PRODRUGS AND THEIR USE APEH, ALDH1A2, UGT1A9 CTSL 12/4885CTSS 653/4885CTSK 586/4885
US-20200131173-A1 VMAT2 INHIBITOR COMPOUNDS AND COMPOSITIONS THEREOF SLC18A2, SLC6A2, SLC18A3 CTSL 3998/4885CTSS 2297/4885CTSK 2685/4885
US-20130296245-A1 PROLINAMIADE DERIVATIVES AS THROMBIN INHIBITOR, PREPRARATION METHOD AND APPLICATION THEREOF PREP, TFPI, PEPD CTSL 66/4885CTSS 280/4885CTSK 265/4885
US-10905681-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 CTSL 12/4885CTSS 653/4885CTSK 586/4885
US-20160176841-A1 SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS SSB, TLR7, TLR8 CTSL 1162/4885CTSS 1423/4885CTSK 1037/4885
US-12122765-B2 Methods and intermediates for preparing therapeutic compounds CYP11A1, CYP11B1, CYP11B2 CTSL 216/4885CTSS 728/4885CTSK 1742/4885
US-12616676-B2 Preparation method and use of modified hydrophobic excipient CETP, LIPA, MTTP CTSL 1366/4885CTSS 2330/4885CTSK 2251/4885
US-20200289475-A1 RILUZOLE PRODRUGS AND THEIR USE APEH, ALDH1A2, UGT1A9 CTSL 12/4885CTSS 653/4885CTSK 586/4885
US-20210395299-A1 NOVEL DIPEPTIDE COMPOUNDS AND USES THEREOF PEPD, SERPINC1, VIP CTSL 174/4885CTSS 745/4885CTSK 418/4885
US-20040102646-A1 Method of resolving optical isomers of amino acid derivative ALAD, AAAS, BCAT1 CTSL 1559/4885CTSS 4304/4885CTSK 4361/4885
US-20220380340-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND TPO, TFPI, TFPI2 CTSL 2655/4885CTSS 2588/4885CTSK 1838/4885
US-20040106619-A1 Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient NONO, NAA15, USO1 CTSL 2757/4885CTSS 3155/4885CTSK 3918/4885
US-20180036290-A1 RILUZOLE PRODRUGS AND THEIR USE APEH, ALDH1A2, UGT1A9 CTSL 12/4885CTSS 653/4885CTSK 586/4885
US-20090306053-A1 Highly selective rho-kinase inhibitor ROCK1, ROCK2, RHOT2 CTSL 4319/4885CTSS 3303/4885CTSK 2990/4885
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE IL6ST, GFRA3, GFRA1 CTSL 145/4885CTSS 1265/4885CTSK 1499/4885
US-20220213111-A1 SUBSTITUTED HETEROCYCLES AS CYCLIC TREX1 INHIBITORS TMX1, TREH, TSNAX CTSL 3028/4885CTSS 2838/4885CTSK 3200/4885
US-20160016967-A1 ARYL AMIDE-BASED KINASE INHIBITORS AAK1, ADCK1, NCK1 CTSL 4532/4885CTSS 4233/4885CTSK 1377/4885
US-20190085026-A1 AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF PRCP, SF3B5, GBA1 CTSL 64/4885CTSS 139/4885CTSK 201/4885
US-11932628-B2 Selective small molecule peptidomimetic melanocortin ligands MC1R, MC3R, MC4R CTSL 3505/4885CTSS 3135/4885CTSK 2752/4885
US-20040152740-A1 Arylglycine derivatives for use as glycine transport inhibitors SLC1A2, SLC6A7, SLC1A1 CTSL 2736/4885CTSS 1973/4885CTSK 2451/4885
US-10364269-B2 Processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof SF3B5, PRCP, GBA1 CTSL 81/4885CTSS 132/4885CTSK 252/4885
US-20050075281-A1 peptide antibiotics comprising lysobactin derivatives used for treatment and/or prophylaxis of bacterial infectious diseases; cyclic peptides VIP, LNPEP, HAMP CTSL 65/4885CTSS 459/4885CTSK 393/4885
US-20170144969-A1 ANTIMICROBIAL CONJUGATES, METHOD FOR PRODUCTION AND USES THEREOF SRM, SMS, SMOX CTSL 601/4885CTSS 719/4885CTSK 1412/4885
US-20100130558-A1 NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS CACNA1C, ORAI1, CACNA1S CTSL 1186/4885CTSS 1732/4885CTSK 2107/4885
US-10253027-B2 Aryl lactam kinase inhibitors AAK1, ADCK1, ANKK1 CTSL 3992/4885CTSS 3931/4885CTSK 1026/4885
US-12005046-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 CTSL 12/4885CTSS 653/4885CTSK 586/4885
US-20130012537-A1 3,8-DIAMINOTETRAHYDROQUINOLINE DERIVATIVE MC2R, GHRHR, REN CTSL 2793/4885CTSS 3940/4885CTSK 4355/4885
US-20130184252-A1 DIHYDROPYRROLONAPHTHYRIDINONE COMPOUNDS AS INHIBITORS OF JAK JAK2, JAK1, JAK3 CTSL 2201/4885CTSS 3087/4885CTSK 2726/4885
US-20200390760-A1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA PIK3CD, PIK3CA, PI4KA CTSL 2296/4885CTSS 3381/4885CTSK 1442/4885
US-20250269043-A1 TARGETED BIFUNCTIONAL DEGRADERS SMURF2, SMURF1, MDM2 CTSL 577/4885CTSS 346/4885CTSK 534/4885
US-20240018161-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B CTSL 3165/4885CTSS 2960/4885CTSK 2874/4885
US-20170283377-A1 ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE AR, UTS2R, MC2R CTSL 4372/4885CTSS 3968/4885CTSK 4541/4885
US-20220388947-A1 Nitrogen-containing Derivative of Substituted Phenol Hydroxy Acid Ester, and Preparation and Use Thereof EGLN2, EGLN3, HPD CTSL 3363/4885CTSS 3527/4885CTSK 4269/4885
US-11583538-B2 Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors TMX1, P2RX1, TCOF1 CTSL 3478/4885CTSS 3702/4885CTSK 4170/4885
US-20220111056-A1 DRUG-LOADED EMULSION SLC43A1, SLC7A1, CETP CTSL 1794/4885CTSS 3871/4885CTSK 4165/4885
US-20110230539-A1 Small Molecule Inhibitors of N-Terminus Activation of the Androgen Receptor AR, KLK3, NR5A1 CTSL 2310/4885CTSS 1778/4885CTSK 2207/4885
US-20040248811-A1 Compound and derivative of gabapentin GABRA4, NPY4R, CNR2 CTSL 4427/4885CTSS 4162/4885CTSK 4212/4885
US-10800809-B2 Processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof SF3B5, PRCP, GBA1 CTSL 81/4885CTSS 132/4885CTSK 252/4885
US-11911369-B2 Prodrugs of riluzole and their method of use APEH, UGT1A9, ALDH3A1 CTSL 6/4885CTSS 503/4885CTSK 543/4885
US-20130296281-A1 Aryl Substituted Indoles and Their Use as Blockers of Sodium Channels SCN5A, TRPV1, TRPV5 CTSL 3744/4885CTSS 2773/4885CTSK 3507/4885
US-11040970-B2 VMAT2 inhibitor compounds and compositions thereof SLC18A2, SLC6A2, SLC18A3 CTSL 3998/4885CTSS 2297/4885CTSK 2685/4885
US-10208023-B2 Heterocyclic inhibitors of the sodium channel SCN1B, TRPV1, SCN1A CTSL 3400/4885CTSS 1444/4885CTSK 3043/4885
US-20120053162-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS UGT2B7, BCCIP, ABCG2 CTSL 3064/4885CTSS 1720/4885CTSK 2865/4885
US-20160326111-A1 ARYL SUBSTITUTED INDOLES AND THE USE THEREOF TRPC5, TRPV5, TRPV1 CTSL 3565/4885CTSS 2491/4885CTSK 3321/4885
US-20250281424-A1 SMALL MOLECULE ANTAGONISTS OF PF4 PF4, F12, F2 CTSL 3865/4885CTSS 3675/4885CTSK 3949/4885
US-20160016939-A1 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL SCN1B, TRPV1, SCN1A CTSL 3400/4885CTSS 1444/4885CTSK 3043/4885
US-20160024093-A1 IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE IRAK2, IRAK1, GRB2 CTSL 4683/4885CTSS 4728/4885CTSK 3841/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.