Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24059732 | 0.88 | HRH3 (0.44) | HRH3PDE4BALDH1A1LMNATP53 | |
| SCHEMBL21144549 | 0.76 | PDE4B (0.47) | HRH3PDE4BALDH1A1LMNATP53 | |
| SCHEMBL19852009 | 0.75 | HRH3 (0.44) | HRH3PDE4BALDH1A1MEN1KMT2A | |
| SCHEMBL11391393 | 0.75 | PDE4B (0.46) | HRH3PDE4BALDH1A1LMNATP53 | |
| SCHEMBL19851997 | 0.72 | DRD2 (0.50) | ALDH1A1MEN1KMT2A | |
| SCHEMBL11397250 | 0.71 | PDE3B (0.48) | HRH3PDE4BALDH1A1LMNATP53 | |
| SCHEMBL17504206 | 0.70 | TP53 (0.54) | ALDH1A1LMNATP53MEN1KMT2A | |
| SCHEMBL11397697 | 0.70 | THRB (0.45) | HRH3PDE4BALDH1A1LMNATP53 | |
| SCHEMBL11526592 | 0.70 | TP53 (0.43) | PDE4BALDH1A1LMNATP53MEN1 | |
| SCHEMBL17518406 | 0.70 | LMNA (0.54) | ALDH1A1LMNATP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026371-A1 | DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2018-02-08 | — | — | WO | disclosed |