Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 5/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21071614 | 0.81 | HTR7 (0.45) | HTR7SIGMAR1HTR1AMEN1KMT2A | |
| SCHEMBL21145387 | 0.77 | SLC6A2 (0.42) | OPRM1HTR7SIGMAR1HTR1AMEN1 | |
| SCHEMBL19852349 | 0.67 | SIGMAR1 (0.52) | HTR7SIGMAR1HTR1AHTR2CDRD2 | |
| SCHEMBL19852462 | 0.66 | OPRM1 (0.40) | OPRM1HTR7HTR1AMEN1KMT2A | |
| SCHEMBL19852300 | 0.66 | HTR7 (0.47) | HTR7SIGMAR1HTR1AMEN1KMT2A | |
| SCHEMBL19852152 | 0.65 | PDE4A (0.43) | HTR7MEN1KMT2APDE4APDE4B | |
| SCHEMBL25619737 | 0.64 | LMNA (0.50) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL19852460 | 0.60 | KCNH2 (0.46) | SIGMAR1HTR1AMEN1KMT2AADRA1D | |
| SCHEMBL19374778 | 0.60 | SMN1; SMN2 (0.52) | OPRM1HTR1AMEN1KMT2ACYP2D6 | |
| SCHEMBL19852164 | 0.60 | SIGMAR1 (0.44) | HTR7SIGMAR1HTR1AHTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026371-A1 | DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS | SUNOVION PHARMACEUTICALS INC. (US) | 2018-02-08 | — | — | WO | disclosed |