Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 17/20 | 0.33 |
| ▸ | CIT | O14578 | 3/20 | 0.33 |
| ▸ | GAK | O14976 | 3/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.33 |
| ▸ | BMP2K | Q9NSY1 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29306465 | 0.74 | RXRA (0.33) | L3MBTL1 | |
| SCHEMBL21257678 | 0.74 | ALDH1A1 (0.33) | L3MBTL1 | |
| SCHEMBL21398692 | 0.73 | USP2 (0.39) | SMARCA2AAK1CITGAKMKNK1 | |
| SCHEMBL11994360 | 0.72 | SMARCA2 (0.38) | SMARCA2AAK1CITGAKMKNK1 | |
| SCHEMBL24568624 | 0.72 | SMARCA2 (0.35) | SMARCA2AAK1CITGAKMKNK1 | |
| SCHEMBL27406023 | 0.69 | SMARCA2 (0.36) | SMARCA2AAK1CITGAKMKNK1 | |
| SCHEMBL17981895 | 0.69 | AAK1 (0.36) | SMARCA2AAK1CITGAKMKNK1 | |
| SCHEMBL17000211 | 0.69 | SMARCA2 (0.36) | SMARCA2AAK1CITGAKMKNK1 | |
| SCHEMBL15581118 | 0.69 | ACHE (0.40) | CYP3A4L3MBTL1SLC6A2 | |
| SCHEMBL28382973 | 0.68 | MEN1 (0.49) | CYP3A4SLC6A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037568-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037568-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | TPMT, TET1, DNMT1 | SMARCA2 446/4885AAK1 2388/4885CIT 3996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.