Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | HRAS | P01112 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1240611 | 0.82 | HRAS (0.46) | ATMTAAR1SIGMAR1HRASTSHR | |
| SCHEMBL437919 | 0.79 | MAOA (0.48) | L3MBTL1SIGMAR1HRASTSHRNPC1 | |
| SCHEMBL1829762 | 0.79 | NPC1 (0.50) | ATMTAAR1L3MBTL1SIGMAR1HRAS | |
| SCHEMBL19853459 | 0.78 | MEN1 (0.65) | MEN1KMT2ASIGMAR1HRASMAPT | |
| SCHEMBL16352091 | 0.78 | NPC1 (0.45) | ATMTAAR1HRASTSHRNPC1 | |
| SCHEMBL8150074 | 0.78 | HRAS (0.50) | HRASTSHRNPC1RAB9AIDO1 | |
| Hydrochloric Acid SCHEMBL6436425 | 0.78 | GAA (0.50) | ATMTAAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL10948517 | 0.78 | NPC1 (0.47) | TAAR1HRASCYP3A4TSHRNPC1 | |
| SCHEMBL17805686 | 0.78 | HRAS (0.46) | MEN1KMT2AHRASTSHRNPC1 | |
| SCHEMBL19853411 | 0.77 | TAAR1 (0.48) | TAAR1SIGMAR1HRASTSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026792-A1 | SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |