Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437919 | 0.81 | MAOA (0.48) | HRASTSHRNPC1RAB9AIDO1 | |
| SCHEMBL1829762 | 0.81 | NPC1 (0.50) | HRASTSHRNPC1RAB9AIDO1 | |
| SCHEMBL1240611 | 0.79 | HRAS (0.46) | HRASTSHRNPC1RAB9AIDO1 | |
| Hydrochloric Acid SCHEMBL6436425 | 0.79 | GAA (0.50) | HRASTSHRNPC1RAB9AIDO1 | |
| SCHEMBL10948517 | 0.79 | NPC1 (0.47) | HRASTSHRNPC1RAB9AIDO1 | |
| SCHEMBL8150074 | 0.79 | HRAS (0.50) | HRASTSHRNPC1RAB9ATDP1 | |
| Hydrochloric Acid SCHEMBL10949329 | 0.78 | AGXT (0.48) | HRASTSHRNPC1RAB9AIDO1 | |
| SCHEMBL10693909 | 0.78 | SIGMAR1 (0.57) | MEN1KMT2ABCHE | |
| SCHEMBL19853420 | 0.78 | ATM (0.52) | HRASTSHRNPC1RAB9AIDO1 | |
| SCHEMBL8724007 | 0.76 | HRAS (0.47) | HRASTSHRNPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121667-B1 | CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF | SQUIBB & SONS LLC (US) | 2016-06-08 | — | — | EP | disclosed |