Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21034523 | 0.85 | OPRM1 (0.42) | GRIN2BGRIN2CMMP2MMP9ADAM17 | |
| SCHEMBL19853726 | 0.85 | OPRM1 (0.42) | GRIN2BGRIN2CMMP2MMP9ADAM17 | |
| SCHEMBL19853697 | 0.82 | RIPK1 (0.37) | MMP2MMP9ADAM17ALDH1A1RIPK1 | |
| SCHEMBL30801716 | 0.80 | CCR1 (0.51) | CYP2D6CYP2C19DPP4KCNH2DPP7 | |
| SCHEMBL19853693 | 0.76 | RIPK1 (0.48) | ALDH1A1RIPK1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL23467759 | 0.74 | GRIN2B (0.36) | GRIN2BGRIN2CALDH1A1RIPK1CYP2D6 | |
| SCHEMBL19629074 | 0.74 | GRIN2B (0.51) | GRIN2BGRIN2C | |
| SCHEMBL30801671 | 0.74 | CCR1 (0.45) | ALDH1A1DPP4KCNH2DPP7 | |
| SCHEMBL22087702 | 0.74 | GRIN2B (0.41) | GRIN2BGRIN2CALDH1A1RIPK1CYP2D6 | |
| SCHEMBL19853347 | 0.74 | GRIN2B (0.41) | GRIN2BGRIN2CALDH1A1RIPK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026763-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |