Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21034922 | 0.92 | OPRK1 (0.35) | OPRK1APEX1BLM | |
| SCHEMBL19854883 | 0.79 | GRIN2B (0.38) | OPRK1 | |
| SCHEMBL19853787 | 0.78 | BLM (0.35) | APEX1BLM | |
| SCHEMBL19853725 | 0.77 | APEX1 (0.32) | APEX1BLM | |
| SCHEMBL19853794 | 0.76 | APEX1 (0.35) | APEX1BLM | |
| SCHEMBL19854298 | 0.74 | OPRM1 (0.34) | APEX1BLM | |
| SCHEMBL19839384 | 0.74 | BLM (0.39) | APEX1BLM | |
| SCHEMBL19853789 | 0.72 | APEX1 (0.47) | APEX1BLM | |
| SCHEMBL19853769 | 0.69 | TSHR (0.44) | APEX1BLM | |
| SCHEMBL24634181 | 0.69 | GRIN2B (0.41) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026763-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |