SCHEMBL19854635

SCHEMBL19854635

O=C1c2ccc(Br)cc2NC1C1Nc2cc(Br)ccc2C1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 1/20 0.43
TDP2 O95551 1/20 0.41
TGM2 P21980 1/20 0.40
CES1 P23141 1/20 0.40
CMA1 P23946 1/20 0.39
AHR P35869 1/20 0.39
PTPRC P08575 1/20 0.38
BCL2 P10415 2/20 0.37
MCL1 Q07820 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA4 P22748 1/20 0.37
CA7 P43166 1/20 0.37
CA9 Q16790 1/20 0.37
PARP10 Q53GL7 1/20 0.37
PARP11 Q9NR21 1/20 0.37
MAOA P21397 2/20 0.36
MAOB P27338 2/20 0.36
HSP90AA1 P07900 1/20 0.34
TLR9 Q9NR96 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19854691 0.93 PTPRC (0.46) S100A4TDP2TGM2CES1PTPRC
SCHEMBL19931150 0.72 TGM2 (0.59) S100A4TDP2TGM2CES1CMA1
SCHEMBL16986622 0.72 CYP1A2 (0.42) PTPRCCYP1A2MAPK1MEN1KMT2A
SCHEMBL19568178 0.72 TSHR (0.50) S100A4MAOAMAOBMAPK1PDGFRA
SCHEMBL6557130 0.72 TSHR (0.50) S100A4MAOAMAOBMAPK1PDGFRA
SCHEMBL24373457 0.71 GABRA1 (0.43) S100A4TDP2TGM2CES1CMA1
SCHEMBL222096 0.69 PBRM1 (0.46) S100A4TDP2TGM2CES1CMA1
SCHEMBL21067503 0.69 TP53 (0.47) CYP1A2MAPK1
SCHEMBL25986169 0.67 CA1 (0.41) S100A4TDP2TGM2CES1CMA1
SCHEMBL14852055 0.67 TGM2 (0.47) S100A4TGM2CES1PTPRCBCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220136024-A1 PROTECTING GROUP CHEMISTRY FOR CLEAN, REDUCTANT-FREE DYEING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-05-05 US disclosed
US-11203774-B2 Protecting group chemistry for clean, reductant-free dyeing THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-12-21 US disclosed
US-20200325516-A1 PROTECTING GROUP CHEMISTRY FOR CLEAN, REDUCTANT-FREE DYEING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-10-15 US disclosed
US-10704070-B2 Protecting group chemistry for clean, reductant-free dyeing THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-07-07 US disclosed
US-20180037917-A1 PROTECTING GROUP CHEMISTRY FOR CLEAN, REDUCTANT-FREE DYEING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-02-08 US disclosed