SCHEMBL6557130

SCHEMBL6557130

O=C1c2ccccc2NC1C1Nc2ccccc2C1=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.50
LMNA P02545 1/20 0.50
PDGFRA P16234 1/20 0.48
FER P16591 1/20 0.48
LTK P29376 1/20 0.48
CDK8 P49336 1/20 0.48
ACVR1 Q04771 1/20 0.48
LRRK2 Q5S007 1/20 0.48
DYRK1B Q9Y463 1/20 0.48
GSK3B P49841 1/20 0.46
TNKS2 Q9H2K2 6/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
S100A4 P26447 1/20 0.42
POLB P06746 1/20 0.42
ALDH1A1 P00352 4/20 0.40
KDM4E B2RXH2 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19568178 1.00 TSHR (0.50) TSHRLMNAPDGFRAFERLTK
SCHEMBL21135350 0.88 LMNA (0.42) TSHRLMNAPDGFRAFERLTK
SCHEMBL19854691 0.83 PTPRC (0.46) TSHRLMNAPDGFRAFERLTK
SCHEMBL21135597 0.79 RET (0.42) TSHRLMNAPDGFRAFERLTK
SCHEMBL9899341 0.78 IDO1 (0.45) TSHRLMNAPDGFRAFERLTK
SCHEMBL21135349 0.78 L3MBTL1 (0.45) TSHRLMNAPDGFRAFERLTK
SCHEMBL16747960 0.76 MEN1 (0.48) LMNAGSK3BMAOAKMT2AMEN1
SCHEMBL19492450 0.76 TSHR (0.47) TSHRLMNAPDGFRAFERLTK
SCHEMBL5807797 0.76 LMNA (0.47) TSHRLMNAPDGFRAFERLTK
SCHEMBL31739367 0.76 TSHR (0.47) TSHRLMNAPDGFRAFERLTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0835093-B1 HAIR DYE AGENTS WITH AT LEAST ONE CONDITIONER HANS SCHWARZKOPF & HENKEL GMBH (DE) 2004-03-10 EP claimed
EP-0835093-A1 HAIR DYE AGENTS WITH AT LEAST ONE CONDITIONER Hans Schwarzkopf GmbH & Co. KG (DE) 1998-04-15 EP claimed
WO-1997001323-A1 HAIR DYE AGENTS WITH AT LEAST ONE CONDITIONER HANS SCHWARZKOPF GMBH (DE) 1997-01-16 WO claimed
US-20220136024-A1 PROTECTING GROUP CHEMISTRY FOR CLEAN, REDUCTANT-FREE DYEING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-05-05 US disclosed
US-11203774-B2 Protecting group chemistry for clean, reductant-free dyeing THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-12-21 US disclosed
US-11166934-B2 Pharmaceutical composition for preventing or treating allergic diseases such as asthma or atopy including baicalein as active ingredient AZCURIS CO., LTD. (KR) 2021-11-09 US disclosed
US-20210214888-A1 PROCESS FOR DYEING TEXTILES AND ENZYMES USED THEREIN SANKO TEKSTIL ISLETMELERI SAN. VE TIC. A.S. (TR) 2021-07-15 US disclosed
US-20200352868-A1 CAPSULE FOR TREATING ULCERATIVE COLITIS FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE (JP) 2020-11-12 US disclosed
US-20200345645-A1 COMPOSITIONS COMPRISING INDIGO AND/OR AN INDIGO DERIVATIVE AND METHODS OF USE THEREOF AZORA THERAPEUTICS, INC. 2020-11-05 US disclosed
US-20200325516-A1 PROTECTING GROUP CHEMISTRY FOR CLEAN, REDUCTANT-FREE DYEING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-10-15 US disclosed
US-10738192-B2 Process for the preparation of indigo carmine DISHMAN CARBOGEN AMCIS LIMITED (IN) 2020-08-11 US disclosed
US-10704070-B2 Protecting group chemistry for clean, reductant-free dyeing THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-07-07 US disclosed
US-10287601-B2 Indole-derived compound production BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (US) 2019-05-14 US disclosed
US-20180037917-A1 PROTECTING GROUP CHEMISTRY FOR CLEAN, REDUCTANT-FREE DYEING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-02-08 US disclosed
US-20170204424-A1 INDOLE-DERIVED COMPOUND PRODUCTION BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIV (US) 2017-07-20 US disclosed
EP-0835093-B1 HAIR DYE AGENTS WITH AT LEAST ONE CONDITIONER HANS SCHWARZKOPF & HENKEL GMBH (DE) 2004-03-10 EP disclosed
US-6129770-A HAIR COLOR TREATMENT IMPROVING THE STRUCTURE OF THE HAIR DURING THE ACTUAL COLORING PROCESS AND ELIMINATING THE NEED FOR THE USUAL POST-COLORING TREATMENTS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (KGAA) (DE) 2000-10-10 US disclosed
EP-0835093-A1 HAIR DYE AGENTS WITH AT LEAST ONE CONDITIONER Hans Schwarzkopf GmbH & Co. KG (DE) 1998-04-15 EP disclosed
WO-1997001323-A1 HAIR DYE AGENTS WITH AT LEAST ONE CONDITIONER HANS SCHWARZKOPF GMBH (DE) 1997-01-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10287601-B2 Indole-derived compound production INMT, IDO1, IDO2 TSHR 2039/4885LMNA 4227/4885PDGFRA 3865/4885
US-20200352868-A1 CAPSULE FOR TREATING ULCERATIVE COLITIS SI, SLC10A2, ALPI TSHR 4188/4885LMNA 4423/4885PDGFRA 4619/4885
US-20170204424-A1 INDOLE-DERIVED COMPOUND PRODUCTION INMT, IDO1, IDO2 TSHR 2039/4885LMNA 4227/4885PDGFRA 3865/4885
US-11166934-B2 Pharmaceutical composition for preventing or treating allergic diseases such as asthma or atopy including baicalein as active ingredient TSLP, JAK1, STAT3 TSHR 1844/4885LMNA 4400/4885PDGFRA 1238/4885
US-20200345645-A1 COMPOSITIONS COMPRISING INDIGO AND/OR AN INDIGO DERIVATIVE AND METHODS OF USE THEREOF AHR, ARNT, IDO1 TSHR 2322/4885LMNA 3428/4885PDGFRA 3281/4885
US-10738192-B2 Process for the preparation of indigo carmine CARM1, IPO5, INMT TSHR 3674/4885LMNA 3957/4885PDGFRA 2774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.