SCHEMBL19854867

SCHEMBL19854867

OCCCNc1c(F)c(F)c(-c2c3nc(c(-c4cccc(O)c4)c4ccc([nH]4)c(-c4c(F)c(F)c(NCCCO)c(F)c4F)c4nc(c(-c5cccc(O)c5)c5ccc2[nH]5)C=C4)C=C3)c(F)c1F

nearest known ligand 0.60

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TERT O14746 3/20 0.38
▸ DHODH Q02127 1/20 0.35
▸ TOP1 P11387 1/20 0.34
▸ CYCS P99999 2/20 0.33
▸ MAPK14 Q16539 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19289802 0.89 HSP90AA1 (0.36) TERTDHODHTOP1MAPK14
SCHEMBL24221269 0.89 DHODH (0.38) TERTDHODHTOP1CYCSMEN1
SCHEMBL19296902 0.89 DHODH (0.36) TERTDHODHTOP1CYCS
SCHEMBL19855754 0.88 TERT (0.41) TERTTOP1CYCSMEN1KMT2A
SCHEMBL17651811 0.84 TOP1 (0.43) TERTDHODHTOP1CYCS
SCHEMBL17651778 0.84 TOP1 (0.43) TERTDHODHTOP1CYCS
SCHEMBL19296891 0.84 ABCG2 (0.37) DHODHTOP1CYCS
SCHEMBL19289582 0.84 DHODH (0.33) DHODHTOP1CYCSMAPK14
SCHEMBL19278958 0.84 DHODH (0.33) TERTDHODHTOP1CYCSMAPK14
SCHEMBL31310006 0.84 DHODH (0.33) TERTDHODHTOP1CYCSMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3201201-B1 SPECIFICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2022-01-26 — — EP disclosed
US-10456375-B2 Specifically meso-substituted porphyrins and chlorins for photodynamic therapy BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2019-10-29 — — US disclosed
US-20180036284-A1 SPECIFICALLY meso-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2018-02-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180036284-A1 SPECIFICALLY meso-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY DHPS, DDT, PPOX TERT 1760/4885DHODH 27/4885TOP1 2038/4885
US-10456375-B2 Specifically meso-substituted porphyrins and chlorins for photodynamic therapy DHPS, DDT, PPOX TERT 1760/4885DHODH 27/4885TOP1 2038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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