Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 13/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487397 | 0.87 | FBP1 (0.49) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL4173702 | 0.84 | RAB9A (0.38) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL5102873 | 0.81 | FBP1 (0.49) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL5104905 | 0.79 | PPARA (0.46) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL3608367 | 0.78 | FBP1 (0.52) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL1549824 | 0.77 | FBP1 (0.58) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL5480955 | 0.76 | FBP1 (0.47) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL5484753 | 0.76 | FBP1 (0.47) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL3904657 | 0.75 | FBP1 (0.52) | PPARAABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL1549946 | 0.75 | PPARA (0.48) | PPARAABCB11CYP1A2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-B1 | NEW BENZIMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2013-03-27 | — | — | EP | disclosed |
| US-8088930-B2 | Benzimidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | ACKERMANN JEAN | 2011-09-29 | — | — | US | disclosed |
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| EP-2314576-A1 | Phenyl derivatives as PPAR agonists | F.HOFFMANN-LA ROCHE AG (CH) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |
| US-20100063101-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | US | disclosed |
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | ACKERMANN JEAN | 2010-02-11 | — | — | US | disclosed |
| EP-1742923-B1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | disclosed |
| EP-1742923-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-17 | — | — | EP | disclosed |
| US-7115611-B2 | Phenyl derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1682508-A1 | PHENYL DERIVATIVES AS PPAR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005105754-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |
| US-20050245589-A1 | Pyrazole phenyl derivatives | HOFFMANN-LA ROCHE INC. | 2005-11-03 | — | — | US | disclosed |
| WO-2005049573-A1 | PHENYL DERIVATIVES AS PPAR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |
| US-20050096337-A1 | Phenyl derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063101-A1 | NEW BENZIMIDAZOLE DERIVATIVES | CYP3A7, ECI1, CYP2B6 | PPARA 322/4885ABCB11 43/4885CYP1A2 54/4885 |
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | PPARD, PPARG, PPARA | PPARA 3/4885ABCB11 555/4885CYP1A2 94/4885 |
| US-20050245589-A1 | Pyrazole phenyl derivatives | PPARD, PPARG, PPARA | PPARA 3/4885ABCB11 555/4885CYP1A2 94/4885 |
| US-20050096337-A1 | Phenyl derivatives, their manufacture and use as pharmaceutical agents | PPARD, PPARA, PPARG | PPARA 2/4885ABCB11 337/4885CYP1A2 94/4885 |
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | PPARD, PPARG, PPARA | PPARA 3/4885ABCB11 555/4885CYP1A2 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.