Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 3/20 | 0.43 |
| ▸ | PYGM | P11217 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1549626 | 1.00 | PYGL (0.43) | PYGLPYGMSTAT6DRD2AKR1C3 | |
| SCHEMBL2640155 | 0.92 | STAT6 (0.43) | PYGLSTAT6DRD2AKR1C3HRH4 | |
| SCHEMBL1931303 | 0.91 | DRD2 (0.47) | PYGLSTAT6DRD2AKR1C3TAS1R3 | |
| SCHEMBL1931683 | 0.91 | DRD2 (0.47) | PYGLSTAT6DRD2AKR1C3TAS1R3 | |
| SCHEMBL1931738 | 0.91 | DRD2 (0.47) | PYGLSTAT6DRD2AKR1C3TAS1R3 | |
| SCHEMBL1550637 | 0.89 | PDGFRB (0.48) | PYGLPYGMSTAT6AKR1C3HRH4 | |
| SCHEMBL1550025 | 0.88 | PYGL (0.48) | PYGLDRD2HRH4CYP51A1EGFR | |
| SCHEMBL1549547 | 0.88 | PDGFRB (0.46) | PYGLPYGMSTAT6DRD2AKR1C3 | |
| SCHEMBL1550160 | 0.88 | FLT3 (0.45) | PYGLPYGMSTAT6DRD2HRH4 | |
| SCHEMBL19856951 | 0.87 | NPC1 (0.47) | STAT6DRD2AKR1C3TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |