Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.40 |
| ▸ | PYGL | P06737 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | CCKBR | P32239 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1931683 | 0.92 | DRD2 (0.47) | STAT6DRD2CYP51A1PYGLHRH4 | |
| SCHEMBL1931303 | 0.92 | DRD2 (0.47) | STAT6DRD2CYP51A1PYGLHRH4 | |
| SCHEMBL1931738 | 0.92 | DRD2 (0.47) | STAT6DRD2CYP51A1PYGLHRH4 | |
| SCHEMBL1549626 | 0.92 | PYGL (0.43) | STAT6DRD2CYP51A1PYGLHRH4 | |
| SCHEMBL19856920 | 0.92 | PYGL (0.43) | STAT6DRD2CYP51A1PYGLHRH4 | |
| SCHEMBL1550025 | 0.90 | PYGL (0.48) | DRD2CYP51A1PYGLHRH4EGFR | |
| SCHEMBL1549547 | 0.90 | PDGFRB (0.46) | STAT6DRD2CYP51A1PYGLHRH4 | |
| SCHEMBL19856894 | 0.90 | DRD2 (0.45) | STAT6DRD2CYP51A1PYGLHRH4 | |
| SCHEMBL19856892 | 0.90 | DRD2 (0.45) | STAT6DRD2CYP51A1PYGLHRH4 | |
| SCHEMBL1550160 | 0.89 | FLT3 (0.45) | STAT6DRD2CYP51A1PYGLHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2312947-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2014-01-01 | — | — | EP | claimed |
| JP-2011529082-A | — | — | 2011-12-01 | — | — | JP | claimed |
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | claimed |
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |