Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19859676 | 0.87 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859674 | 0.87 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859897 | 0.85 | CHRNB2 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859898 | 0.85 | CHRNB2 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859635 | 0.80 | HTR6 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859632 | 0.80 | HTR6 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL24936210 | 0.77 | KDM4C (0.39) | — | |
| SCHEMBL24936213 | 0.77 | PHF8 (0.42) | — | |
| SCHEMBL19859848 | 0.73 | HTR6 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL21085843 | 0.73 | HTR6 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497098-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2019-06-19 | — | — | EP | disclosed |
| WO-2018031877-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. (US) | 2018-02-15 | — | — | WO | disclosed |