Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19859897 | 1.00 | CHRNB2 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859618 | 0.85 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859674 | 0.81 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859676 | 0.81 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859632 | 0.75 | HTR6 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859635 | 0.75 | HTR6 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19867700 | 0.68 | HTR6 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859848 | 0.68 | HTR6 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL21085843 | 0.68 | HTR6 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 | |
| SCHEMBL19859847 | 0.68 | HTR6 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497098-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2019-06-19 | — | — | EP | disclosed |
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. | 2019-06-06 | — | — | US | disclosed |
| WO-2018031877-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. (US) | 2018-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | METAP2, DNPEP, FOLH1 | CHRNB2 3969/4885CHRNB4 4736/4885CHRNA3 4617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.