Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.60 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19859923 | 0.85 | SLC1A3 (0.80) | RAB9ASMN1; SMN2GAASLC1A3SLC1A2 | |
| SCHEMBL19860037 | 0.84 | NOTUM (0.55) | — | |
| SCHEMBL31643225 | 0.80 | RAB9A (1.00) | RAB9ASMN1; SMN2GAASLC1A3SLC1A2 | |
| SCHEMBL14152982 | 0.80 | SLC1A3 (0.66) | RAB9ASMN1; SMN2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL14152969 | 0.80 | SLC1A3 (0.66) | RAB9ASMN1; SMN2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5907650 | 0.79 | RAB9A (0.80) | RAB9ASMN1; SMN2GAASLC1A3SLC1A2 | |
| SCHEMBL31136099 | 0.77 | RAB9A (0.78) | RAB9ASMN1; SMN2GAASLC1A3SLC1A2 | |
| SCHEMBL1913977 | 0.75 | ALDH1A1 (0.73) | RAB9ASMN1; SMN2GAAALDH1A1MEN1 | |
| SCHEMBL1285643 | 0.75 | ALDH1A1 (0.73) | RAB9ASMN1; SMN2GAAALDH1A1MEN1 | |
| SCHEMBL31152634 | 0.75 | ALDH1A1 (0.73) | RAB9ASMN1; SMN2GAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |