Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 13/20 | 0.80 |
| ▸ | SLC1A2 | P43004 | 13/20 | 0.80 |
| ▸ | SLC1A1 | P43005 | 13/20 | 0.80 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20190119 | 0.86 | LTA4H (0.70) | SLC1A3SLC1A2SLC1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10908490 | 0.86 | LTA4H (0.70) | SLC1A3SLC1A2SLC1A1RAB9ASMN1; SMN2 | |
| SCHEMBL29687817 | 0.86 | LTA4H (0.70) | SLC1A3SLC1A2SLC1A1RAB9ASMN1; SMN2 | |
| SCHEMBL19859922 | 0.85 | RAB9A (0.66) | SLC1A3SLC1A2SLC1A1RAB9ASMN1; SMN2 | |
| SCHEMBL30074475 | 0.83 | CYP1A2 (0.62) | SLC1A3SLC1A2SLC1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8984826 | 0.82 | SLC1A3 (0.81) | SLC1A3SLC1A2SLC1A1GAAMAPT | |
| SCHEMBL15971325 | 0.82 | SLC1A3 (0.81) | SLC1A3SLC1A2SLC1A1GAAMAPT | |
| SCHEMBL2313979 | 0.82 | SLC1A3 (0.81) | SLC1A3SLC1A2SLC1A1GAAMAPT | |
| SCHEMBL19860041 | 0.82 | ROCK2 (0.59) | SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL31643225 | 0.80 | RAB9A (1.00) | SLC1A3SLC1A2SLC1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |