Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | EEF2K | O00418 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30986004 | 0.98 | RAB9A (0.74) | RAB9ANPC1KMT2AHDAC1HDAC2 | |
| SCHEMBL14372234 | 0.88 | RAB9A (0.56) | RAB9ANPC1KMT2AKDM4ELMNA | |
| SCHEMBL25683723 | 0.84 | RAB9A (0.97) | RAB9ANPC1KMT2ATHRBPANK3 | |
| SCHEMBL30008966 | 0.83 | THRB (0.69) | RAB9ANPC1KMT2AHDAC1HDAC2 | |
| SCHEMBL11061389 | 0.83 | RAB9A (1.00) | RAB9ANPC1KMT2ATHRBPANK3 | |
| SCHEMBL14014929 | 0.82 | RAB9A (0.68) | RAB9ANPC1KMT2AKDM4ETHRB | |
| SCHEMBL19860009 | 0.82 | HDAC2 (0.58) | RAB9ANPC1HDAC1HDAC2KDM4E | |
| SCHEMBL17346760 | 0.82 | RAB9A (0.78) | RAB9ANPC1KMT2AKDM4EHTT | |
| SCHEMBL13735552 | 0.82 | HDAC1 (0.70) | RAB9ANPC1KMT2AHDAC1HDAC2 | |
| SCHEMBL30008791 | 0.81 | EEF2K (0.69) | KMT2AHDAC1HDAC2HDAC3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890172-B2 | Inhibitors of histone deacetylase | THE BROAD INSTITUTE, INC. (US) | 2018-02-13 | — | — | US | disclosed |