Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.68 |
| ▸ | PRMT3 | O60678 | 4/20 | 0.60 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20280473 | 0.91 | NOTUM (0.61) | NOTUMPRMT3IMPDH2ROCK2 | |
| SCHEMBL19860100 | 0.86 | NOTUM (0.65) | NOTUMPRMT3IMPDH2ROCK2 | |
| SCHEMBL19860096 | 0.86 | NOTUM (0.65) | NOTUMPRMT3IMPDH2 | |
| SCHEMBL12201798 | 0.84 | PRMT3 (0.64) | NOTUMPRMT3IMPDH2ROCK2ROCK1 | |
| SCHEMBL12202000 | 0.84 | NOTUM (0.76) | NOTUMPRMT3IMPDH2ROCK2ROCK1 | |
| SCHEMBL4428374 | 0.84 | NOTUM (0.62) | NOTUMPRMT3IMPDH2ROCK2ROCK1 | |
| SCHEMBL30176801 | 0.83 | KDM4E (0.66) | NOTUMPRMT3IMPDH2ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL111600 | 0.83 | PRMT3 (0.62) | NOTUMPRMT3IMPDH2ROCK2ROCK1 | |
| SCHEMBL20262924 | 0.83 | KDM4E (0.66) | NOTUMPRMT3IMPDH2ROCK2ROCK1 | |
| SCHEMBL19860095 | 0.82 | IMPDH2 (0.62) | NOTUMPRMT3IMPDH2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |