Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.62 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 4/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860100 | 0.87 | NOTUM (0.65) | NOTUMIMPDH2PRMT3ROCK2 | |
| SCHEMBL19860094 | 0.84 | NOTUM (0.68) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL19860063 | 0.83 | NOTUM (0.64) | NOTUMIMPDH2PRMT3ROCK2 | |
| SCHEMBL12201759 | 0.82 | IMPDH2 (0.61) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL28407298 | 0.82 | KMT2A (0.62) | — | |
| SCHEMBL2162926 | 0.82 | NOTUM (0.59) | NOTUMIMPDH2PRMT3ROCK2 | |
| SCHEMBL12202000 | 0.82 | NOTUM (0.76) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| SCHEMBL19860096 | 0.82 | NOTUM (0.65) | NOTUMIMPDH2PRMT3 | |
| Hydrochloric Acid SCHEMBL3564762 | 0.81 | IMPDH2 (0.59) | NOTUMIMPDH2PRMT3ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL2162309 | 0.81 | IMPDH2 (0.59) | NOTUMIMPDH2PRMT3ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455647-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110319390-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| EP-2118064-A2 | 6-AMINOISOQUINOLINE COMPOUNDS USEFUL AS KINASE MODULATORS | AERIE PHARMACEUTICALS, INC. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008086269-A2 | 6-AMINOISOQUINOLINE COMPOUNDS USEFUL AS KINASE MODULATORS | AERIE PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319390-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | NOTUM 3635/4885IMPDH2 2131/4885PRMT3 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.