Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.58 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 7/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860123 | 0.90 | IMPDH2 (0.71) | IMPDH2PRMT3NOTUMROCK2 | |
| SCHEMBL14124401 | 0.89 | IMPDH2 (0.61) | IMPDH2PRMT3NAMPTNOTUMROCK2 | |
| SCHEMBL19860122 | 0.83 | IMPDH2 (0.56) | IMPDH2PRMT3NOTUMROCK2 | |
| SCHEMBL14124404 | 0.81 | HDAC1 (0.62) | IMPDH2PRMT3NOTUMNPC1ALDH1A1 | |
| SCHEMBL2164137 | 0.80 | PRMT3 (0.69) | IMPDH2PRMT3NAMPTNOTUMROCK2 | |
| SCHEMBL3111893 | 0.79 | IMPDH2 (0.72) | IMPDH2PRMT3NAMPTROCK2MEN1 | |
| SCHEMBL2162616 | 0.79 | IMPDH2 (0.70) | IMPDH2PRMT3NOTUMROCK2ALDH1A1 | |
| SCHEMBL2162460 | 0.78 | KMT2A (0.67) | NAMPTROCK2MEN1NPC1ALDH1A1 | |
| SCHEMBL4432783 | 0.77 | IMPDH2 (0.65) | IMPDH2PRMT3NAMPTROCK2MEN1 | |
| SCHEMBL3566775 | 0.77 | PRMT3 (0.72) | IMPDH2PRMT3NOTUMROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |