Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 7/20 | 0.54 |
| ▸ | RHOC | P08134 | 1/20 | 0.52 |
| ▸ | RHOA | P61586 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860123 | 0.89 | IMPDH2 (0.71) | IMPDH2NOTUMROCK2PRMT3 | |
| SCHEMBL20353462 | 0.84 | IMPDH2 (0.78) | IMPDH2ROCK2PRMT3TRPV1 | |
| SCHEMBL19860121 | 0.83 | IMPDH2 (0.58) | IMPDH2NOTUMROCK2PRMT3 | |
| SCHEMBL20353576 | 0.79 | IMPDH2 (0.76) | IMPDH2NOTUMROCK2PRMT3 | |
| SCHEMBL19860124 | 0.79 | IMPDH2 (0.59) | IMPDH2NOTUMPRMT3 | |
| SCHEMBL2162755 | 0.78 | NOTUM (0.62) | IMPDH2NOTUMROCK2PRMT3 | |
| SCHEMBL19860106 | 0.77 | ROCK1 (0.57) | IMPDH2NOTUMROCK2PRMT3 | |
| SCHEMBL16056718 | 0.77 | ROCK2 (0.56) | IMPDH2NOTUMROCK2PRMT3 | |
| SCHEMBL19860103 | 0.77 | NOTUM (0.56) | IMPDH2NOTUMROCK2PRMT3 | |
| SCHEMBL2163047 | 0.77 | NOTUM (0.65) | IMPDH2NOTUMROCK2PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |