Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
| ▸ | CCR9 | P51686 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16442052 | 0.90 | CDC7 (0.38) | CDC7CDK2KMT2AMAP3K5CCR9 | |
| SCHEMBL13732447 | 0.83 | DGAT1 (0.39) | CDC7CDK2KMT2ACCR9MCL1 | |
| SCHEMBL29777185 | 0.83 | DGAT1 (0.39) | CDC7CDK2KMT2ACCR9MCL1 | |
| SCHEMBL28521488 | 0.80 | CDC7 (0.41) | CDC7CDK2KMT2AMAP3K5CCR9 | |
| SCHEMBL19861615 | 0.75 | MEN1 (0.33) | KMT2A | |
| SCHEMBL23229422 | 0.74 | CXCR3 (0.30) | — | |
| SCHEMBL28656926 | 0.74 | GRIN2B (0.43) | CDC7CDK2KMT2AMCL1 | |
| SCHEMBL23915418 | 0.73 | DUT (0.36) | — | |
| SCHEMBL24805178 | 0.73 | DGAT1 (0.39) | CDC7CDK2KMT2ACCR9 | |
| SCHEMBL24493506 | 0.72 | HTR2C (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890152-B2 | Aminopyrimidine compounds as inhibitors of T790M containing EGFR mutants | GENENTECH, INC. (US) | 2018-02-13 | — | — | US | disclosed |