Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31376396 | 0.83 | BRD4 (0.36) | MEN1KMT2AKCNH2NPC1RAB9A | |
| SCHEMBL15749768 | 0.83 | BRD4 (0.36) | MEN1KMT2AKCNH2NPC1RAB9A | |
| SCHEMBL19861608 | 0.75 | CDC7 (0.37) | KMT2A | |
| SCHEMBL19966633 | 0.71 | — | — | |
| SCHEMBL19966105 | 0.68 | — | — | |
| SCHEMBL22045563 | 0.68 | FGFR1 (0.32) | MEN1KMT2A | |
| SCHEMBL21089928 | 0.68 | — | — | |
| SCHEMBL23229422 | 0.68 | CXCR3 (0.30) | — | |
| SCHEMBL22045264 | 0.67 | FGFR1 (0.32) | — | |
| SCHEMBL20752549 | 0.67 | KCNH2 (0.32) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890152-B2 | Aminopyrimidine compounds as inhibitors of T790M containing EGFR mutants | GENENTECH, INC. (US) | 2018-02-13 | — | — | US | disclosed |