Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23314658 | 0.84 | TSHR (0.36) | TSHRALDH1A1PRKCATDP1L3MBTL1 | |
| SCHEMBL28625413 | 0.82 | TSHR (0.40) | TSHRBIRC2GAASMN1; SMN2 | |
| SCHEMBL13033614 | 0.82 | TSHR (0.40) | TSHRBIRC2GAASMN1; SMN2 | |
| SCHEMBL1891853 | 0.82 | TSHR (0.40) | TSHRBIRC2GAASMN1; SMN2 | |
| SCHEMBL27546947 | 0.79 | TSHR (0.41) | TSHRALDH1A1PRKCATDP1L3MBTL1 | |
| SCHEMBL38033 | 0.76 | SMN1; SMN2 (0.39) | TSHRALDH1A1L3MBTL1NPSR1POLB | |
| SCHEMBL9160535 | 0.76 | TSHR (0.38) | TSHRALDH1A1PRKCATDP1L3MBTL1 | |
| SCHEMBL18532001 | 0.76 | TSHR (0.38) | TSHRALDH1A1PRKCATDP1L3MBTL1 | |
| SCHEMBL9160545 | 0.76 | TSHR (0.38) | TSHRALDH1A1PRKCATDP1L3MBTL1 | |
| SCHEMBL2363539 | 0.76 | TSHR (0.38) | TSHRALDH1A1PRKCATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9891239-B2 | Modulators of pharmacokinetic properties of therapeutics | GILEAD SCIENCES, INC. (US) | 2018-02-13 | — | — | US | disclosed |