Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825651 | 0.84 | ROCK2 (0.45) | MEN1CYP2D6CYP2C19KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL7379790 | 0.83 | ROCK2 (0.44) | MEN1CYP2D6CYP2C19KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL7379773 | 0.83 | ROCK2 (0.44) | MEN1CYP2D6CYP2C19KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL7339178 | 0.83 | ROCK2 (0.44) | MEN1CYP2D6CYP2C19KMT2AMAPT | |
| SCHEMBL18890099 | 0.83 | L3MBTL1 (0.54) | LMNAKDM4EKCNQ2AOC3TDP1 | |
| SCHEMBL18048626 | 0.82 | MAPT (0.45) | MEN1CYP2D6CYP2C19KMT2AMAPT | |
| SCHEMBL819324 | 0.82 | MMP8 (0.51) | MEN1CYP2D6KMT2AKDM4ETDP1 | |
| SCHEMBL9715492 | 0.81 | MAPT (0.50) | MEN1CYP2D6CYP2C19KMT2AMAPT | |
| SCHEMBL15645799 | 0.80 | MMP8 (0.50) | MEN1CYP2D6CYP2C19KMT2AMAPT | |
| SCHEMBL17724586 | 0.79 | KDM4E (0.51) | MEN1CYP2D6CYP2C19KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044326-A1 | LACTAMS AS INHIBITORS OF ROCK | BRISTOL-MYERS SQUIBB COMAPANY (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044326-A1 | LACTAMS AS INHIBITORS OF ROCK | MYLK, ROCK1, RHOA | MEN1 89/4885CYP2D6 3421/4885CYP2C19 2014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.