Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3282095 | 0.93 | HPGD (0.51) | HPGDALDH1A1ALOX12BRCA1HSD17B10 | |
| SCHEMBL2877720 | 0.93 | HPGD (0.51) | HPGDALDH1A1ALOX12BRCA1HSD17B10 | |
| SCHEMBL2989053 | 0.86 | HPGD (0.53) | HPGDALDH1A1ALOX12BRCA1HSD17B10 | |
| SCHEMBL2407742 | 0.86 | HPGD (0.52) | HPGDALDH1A1ALOX12BRCA1HSD17B10 | |
| SCHEMBL1991388 | 0.85 | FTO (0.42) | HPGDALDH1A1ALOX12BRCA1HSD17B10 | |
| SCHEMBL6510685 | 0.84 | HPGD (0.50) | HPGDALDH1A1ALOX12BRCA1HSD17B10 | |
| SCHEMBL2225607 | 0.84 | HPGD (0.53) | HPGDALDH1A1ALOX12BRCA1HSD17B10 | |
| SCHEMBL8815694 | 0.81 | FTO (0.44) | HPGDALDH1A1ALOX12BRCA1HSD17B10 | |
| SCHEMBL5711738 | 0.81 | HPGD (0.45) | HPGDALDH1A1ALOX12BRCA1HSD17B10 | |
| SCHEMBL3468980 | 0.81 | HPGD (0.49) | HPGDALDH1A1ALOX12BRCA1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687609-B1 | FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND | EPOCH BIOSCIENCES INC (US) | 2014-12-10 | — | — | EP | disclosed |
| US-8853132-B2 | Directed synthesis of oligophosphoramidate stereoisomers | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20140045719-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8569515-B2 | Directed synthesis of oligophosphoramidate stereoisomers | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20130022976-A1 | HYPERTHERMOSTABLE ENDONUCLEASE IV SUBSTRATE PROBE | ELITECH HOLDING B.V. | 2013-01-24 | — | — | US | disclosed |
| EP-2370450-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | Roche Diagnostics GmbH (DE) | 2011-10-05 | — | — | EP | disclosed |
| US-20110212861-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | ROCHE DIAGNOSTICS GMBH (DE) | 2011-09-01 | — | — | US | disclosed |
| US-20110151457-A1 | HYPERTHEROMOSTABLE ENDONUCLEASE IV SUBSTRATE PROBE | ELITECH HOLDING B.V. | 2011-06-23 | — | — | US | disclosed |
| US-7759126-B2 | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for amplification (or PCR) analysis | ELITECH HOLDING B.V. (NL) | 2010-07-20 | — | — | US | disclosed |
| WO-2010060599-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | ROCHE DIAGNOSTICS GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |
| WO-2009058852-A2 | MINOR GROOVE BINDER-ENERGY TRANSFER OLIGONUCLEOTIDES AND METHODS FOR THEIR USE | EPOCH BIOSCIENCES, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| US-20080293586-A1 | FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND | EPOCH BIOSCIENCES, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-7381818-B2 | Fluorescent probes containing 5′-minor groove binder, fluorophore and quenching moieties and methods of use thereof | EPOCH BIOSCIENCES, INC. (US) | 2008-06-03 | — | — | US | disclosed |
| EP-1687609-A2 | FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND | Epoch Biosciences, Inc. (US) | 2006-08-09 | — | — | EP | disclosed |
| US-20050214797-A1 | Fluorescent probes for DNA detection by hybridization with improved sensitivity and low background | EPOCH BIOSCIENCES, INC (US) | 2005-09-29 | — | — | US | disclosed |
| WO-2005043127-A2 | FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND | EPOCH BIOSCIENCES, INC. (US) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045719-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | TYMP, TK1, PFAS | HPGD 1546/4885ALDH1A1 1428/4885ALOX12 1285/4885 |
| US-20080293586-A1 | FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND | SSBP1, DDB1, DNA2 | HPGD 3648/4885ALDH1A1 3164/4885ALOX12 4177/4885 |
| US-20110212861-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | TYMP, TK1, PFAS | HPGD 1546/4885ALDH1A1 1428/4885ALOX12 1285/4885 |
| US-20110151457-A1 | HYPERTHEROMOSTABLE ENDONUCLEASE IV SUBSTRATE PROBE | DNASE1, FEN1, UNG | HPGD 756/4885ALDH1A1 681/4885ALOX12 2918/4885 |
| US-20050214797-A1 | Fluorescent probes for DNA detection by hybridization with improved sensitivity and low background | SSBP1, DDB1, DNA2 | HPGD 3648/4885ALDH1A1 3164/4885ALOX12 4177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.