Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 6/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL77644 | 0.82 | ALDH1A1 (0.49) | ALDH1A1HPGDSMN1; SMN2CCR4HTR1A | |
| SCHEMBL2736380 | 0.78 | HTR1A (0.41) | ALDH1A1HPGDSMN1; SMN2CCR4HTR1A | |
| SCHEMBL24065684 | 0.76 | CCR4 (0.35) | ALDH1A1HPGDSMN1; SMN2CCR4HTR1A | |
| SCHEMBL5908628 | 0.74 | HTR1A (0.41) | ALDH1A1HPGDSMN1; SMN2CCR4HTR1A | |
| SCHEMBL27064026 | 0.74 | ALDH1A1 (0.38) | ALDH1A1HPGDSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL19575790 | 0.73 | HTR1A (0.33) | ALDH1A1SMN1; SMN2CCR4HTR1AHTR2A | |
| SCHEMBL25440564 | 0.73 | ALOX5 (0.34) | ALDH1A1HPGDSMN1; SMN2CCR4HTR1A | |
| SCHEMBL2608448 | 0.72 | LMNA (0.43) | ALDH1A1HPGDSMN1; SMN2CCR4HTR1A | |
| SCHEMBL5775322 | 0.71 | HTR1A (0.41) | ALDH1A1HPGDSMN1; SMN2CCR4HTR1A | |
| SCHEMBL4573687 | 0.71 | HTR1A (0.41) | ALDH1A1HPGDSMN1; SMN2CCR4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329299-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2019-06-25 | — | — | US | disclosed |
| US-20180044346-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | TWELVE THERAPEUTICS, INC. | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329299-B2 | Heterocyclic compounds and uses thereof | PIK3CA, AKT1, AKT2 | ALDH1A1 1493/4885HPGD 629/4885SMN1; SMN2 2257/4885 |
| US-20180044346-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | ALDH1A1 3154/4885HPGD 836/4885SMN1; SMN2 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.