Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.38 |
| ▸ | CCR9 | P51686 | 4/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19857771 | 0.85 | TOP2A (0.42) | TOP2ATOP2BALDH1A1SCN8AIDH1 | |
| SCHEMBL19857868 | 0.85 | GABRB1 (0.41) | TOP2ATOP2BALDH1A1S1PR3KCNQ3 | |
| SCHEMBL8254664 | 0.84 | AAK1 (0.39) | S1PR3MEN1KMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL4112748 | 0.82 | CNR2 (0.42) | CNR2IDH1HSP90AA1HSP90AB1 | |
| SCHEMBL13775967 | 0.81 | CNR2 (0.41) | CNR2IDH1HSP90AA1HSP90AB1P2RX1 | |
| SCHEMBL30478220 | 0.80 | HSP90AA1 (0.38) | S1PR3MEN1KMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL13776429 | 0.79 | MEN1 (0.47) | ALDH1A1MEN1KMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL19863786 | 0.78 | CCR9 (0.54) | ALDH1A1CCR9TRPV1MEN1KMT2A | |
| SCHEMBL19939487 | 0.78 | HSP90AA1 (0.39) | ALDH1A1MEN1KMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL4122839 | 0.77 | LMNA (0.46) | ALDH1A1CNR2HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577349-B2 | Quinolinones as inhibitors of translation initiation complex | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-03-03 | — | — | US | disclosed |
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | Sanford Burnham Prebys Medical Discovery Institute | 2018-02-15 | — | — | US | disclosed |
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | Sanford Burnham Prebys Medical Discovery Institute | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | EIF4E, EIF4A1, EIF4A2 | TOP2A 1673/4885TOP2B 2250/4885ALDH1A1 4269/4885 |
| US-10577349-B2 | Quinolinones as inhibitors of translation initiation complex | EIF4E, EIF4A1, EIF4A2 | TOP2A 1673/4885TOP2B 2250/4885ALDH1A1 4269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.