SCHEMBL198638

SCHEMBL198638

NC(Cc1nc[nH]n1)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.49
CYP3A4 P08684 2/20 0.49
PKM P14618 2/20 0.44
ALPI P09923 1/20 0.44
PTGS1 P23219 1/20 0.44
XIAP P98170 1/20 0.44
HSD17B10 Q99714 2/20 0.41
USP2 O75604 2/20 0.41
HIF1A Q16665 2/20 0.41
KDM4E B2RXH2 2/20 0.41
MEN1 O00255 2/20 0.41
LMNA P02545 2/20 0.41
MAPT P10636 2/20 0.41
BLM P54132 2/20 0.41
PMP22 Q01453 2/20 0.41
KMT2A Q03164 2/20 0.41
RGS12 O14924 1/20 0.41
CYP2C9 P11712 1/20 0.41
ALOX15 P16050 1/20 0.41
NFKB1 P19838 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2451002 1.00 SLC7A5 (0.49) SLC7A5CYP3A4PKMALPIPTGS1
SCHEMBL23356093 1.00 SLC7A5 (0.49) SLC7A5CYP3A4PKMALPIPTGS1
SCHEMBL2059137 0.81 ALDH1A1 (0.37) SLC7A5CYP3A4ALDH1A1
Hydrochloric Acid SCHEMBL5814493 0.80 ALDH1A1 (0.39) SLC7A5CYP3A4ALDH1A1
SCHEMBL21689933 0.75 SLC7A5 (0.53) SLC7A5CYP3A4PKMALPIPTGS1
SCHEMBL1769036 0.75 SLC7A5 (0.53) SLC7A5CYP3A4PKMALPIPTGS1
SCHEMBL1769034 0.75 SLC7A5 (0.53) SLC7A5CYP3A4PKMALPIPTGS1
Hydrochloric Acid SCHEMBL20502478 0.73 SLC7A5 (0.52) SLC7A5CYP3A4PKMALPIPTGS1
SCHEMBL5828934 0.73 KIF11 (0.38) SLC7A5CYP3A4
SCHEMBL1891367 0.70 GRIA2 (0.50) SLC7A5CYP3A4PKMALPIPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 615 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240350681-A1 RADIOLABELED MELANOCORTIN 1 RECEPTOR-SPECIFIC ALPHA-MELANOCYTE-STIMULATING HORMONE ANALOGUES FOR IMAGING OR THERAPY PROVINCIAL HEALTH SERVICES AUTHORITY (CA) 2024-10-24 US claimed
US-11992537-B2 Radiolabeled melanocortin 1 receptor-specific alpha-melanocyte-stimulating hormone analogues for imaging or therapy PROVINCIAL HEALTH SERVICES AUTHORITY (CA) 2024-05-28 US claimed
US-20210205483-A1 RADIOLABELED MELANOCORTIN 1 RECEPTOR-SPECIFIC ALPHA-MELANOCYTE-STIMULATING HORMONE ANALOGUES FOR IMAGING OR THERAPY PROVINCIAL HEALTH SERVICES AUTHORITY (CA) 2021-07-08 US claimed
EP-3820886-A1 RADIOLABELED MELANOCORTIN 1 RECEPTOR-SPECIFIC ALPHA-MELANOCYTE-STIMULATING HORMONE ANALOGUES FOR IMAGING OR THERAPY Provincial Health Services Authority (CA) 2021-05-19 EP claimed
US-20170022487-A1 SYNTHETIC CATALYTIC MIMICS OF ESTERASES, LIPASES OR DESATURASES UNIV CALIFORNIA (US) 2017-01-26 US claimed
WO-2015153730-A2 SYNTHETIC CATALYTIC MIMICS OF ESTERASES, LIPASES OR DESATURASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-10-08 WO claimed
US-20150175993-A1 NOVEL SYNZYMES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2015-06-25 US claimed
EP-2864349-A2 DYNAMIC BIOMIMETIC SYNZYME CATALYST, CATALYSIS, AND CATALYTIC SYSTEMS The Regents of The University of California (US) 2015-04-29 EP claimed
WO-2013192430-A2 DYNAMIC BIOMIMETIC SYNZYME CATALYST, CATALYSIS, AND CATALYTIC SYSTEMS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-12-27 WO claimed
US-20130029426-A1 Dual Inducible System for the cSPP System UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) 2013-01-31 US claimed
US-20090035836-A1 MODULATING PH-SENSITIVE BINDING USING NON-NATURAL AMINO ACIDS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2009-02-05 US claimed
US-20050260711-A1 Modulating pH-sensitive binding using non-natural amino acids CALIFORNIA INSITUTE OF TECHNOLOGY 2005-11-24 US claimed
EP-0777458-B1 CONTROL OF HAIR GROWTH UNIV SHEFFIELD (GB) 2000-12-06 EP claimed
US-6020327-A Control of hair growth THE CENTRAL SHEFFIELD UNIVERSITY HOSPITALS NHS TRUST (GB) 2000-02-01 US claimed
EP-0136359-B1 PROCESS FOR PREPARING L-HISTIDINE KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1991-04-03 EP claimed
EP-0136359-A1 PROCESS FOR PREPARING L-HISTIDINE KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1985-04-10 EP claimed
JP-60210994-A None JP disclosed
US-12616761-B2 CXCR4-targeting compounds THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2026-05-05 US disclosed
JP-S60210994-A PREPARATION OF HISTIDINE KYOWA HAKKO KOGYO CO LTD 1985-10-23 JP disclosed
EP-0136359-A1 PROCESS FOR PREPARING L-HISTIDINE KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1985-04-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11992537-B2 Radiolabeled melanocortin 1 receptor-specific alpha-melanocyte-stimulating hormone analogues for imaging or therapy MC1R, MC5R, MC3R SLC7A5 200/4885CYP3A4 4044/4885PKM 3481/4885
US-20050260711-A1 Modulating pH-sensitive binding using non-natural amino acids AARS1, TARBP1, NSUN3 SLC7A5 34/4885CYP3A4 4881/4885PKM 1826/4885
US-20090035836-A1 MODULATING PH-SENSITIVE BINDING USING NON-NATURAL AMINO ACIDS AARS1, TARBP1, NSUN3 SLC7A5 34/4885CYP3A4 4881/4885PKM 1826/4885
US-20210205483-A1 RADIOLABELED MELANOCORTIN 1 RECEPTOR-SPECIFIC ALPHA-MELANOCYTE-STIMULATING HORMONE ANALOGUES FOR IMAGING OR THERAPY MC1R, MC5R, MC3R SLC7A5 200/4885CYP3A4 4044/4885PKM 3481/4885
US-12616761-B2 CXCR4-targeting compounds CXCR4, CXCR2, CXCR3 SLC7A5 354/4885CYP3A4 4779/4885PKM 4002/4885
US-20240350681-A1 RADIOLABELED MELANOCORTIN 1 RECEPTOR-SPECIFIC ALPHA-MELANOCYTE-STIMULATING HORMONE ANALOGUES FOR IMAGING OR THERAPY MC1R, MC3R, MC5R SLC7A5 196/4885CYP3A4 3979/4885PKM 3504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.