Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18811892 | 1.00 | KCNH2 (0.43) | KCNH2KCNA5HTTKMT2AMEN1 | |
| SCHEMBL23381218 | 1.00 | KCNH2 (0.43) | KCNH2KCNA5HTTKMT2AMEN1 | |
| SCHEMBL27272370 | 1.00 | KCNH2 (0.43) | KCNH2KCNA5HTTKMT2AMEN1 | |
| SCHEMBL18403079 | 1.00 | KCNH2 (0.43) | KCNH2KCNA5HTTKMT2AMEN1 | |
| SCHEMBL19505906 | 1.00 | KCNH2 (0.43) | KCNH2KCNA5HTTKMT2AMEN1 | |
| SCHEMBL23920816 | 0.96 | KCNH2 (0.41) | KCNH2KCNA5HTTKMT2AMEN1 | |
| SCHEMBL9224767 | 0.96 | KCNH2 (0.41) | KCNH2KCNA5HTTKMT2AMEN1 | |
| SCHEMBL24901344 | 0.96 | KCNH2 (0.40) | KCNH2KCNA5HTTKMT2AMEN1 | |
| SCHEMBL18387994 | 0.93 | KCNA5 (0.40) | KCNH2KCNA5HTTKMT2AMEN1 | |
| SCHEMBL27426516 | 0.93 | KCNA5 (0.40) | KCNH2KCNA5HTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219974-A1 | ANTHELMINTIC AZA-BENZOTHIOPHENE AND AZA-BENZOFURAN COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2023-07-13 | — | — | US | disclosed |
| US-11560388-B2 | Anthelmintic aza-benzothiophene and aza-benzofuran compounds | BOEHRINGER INGELHEIM VETMEDICA GMBH | 2023-01-24 | — | — | US | disclosed |
| US-20200299304-A1 | ANTHELMINTIC AZA-BENZOTHIOPHENE AND AZA-BENZOFURAN COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2020-09-24 | — | — | US | disclosed |
| US-20200115345-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER, NEUROLOGICAL DISORDERS, ETHANOL WITHDRAWAL, ANXIETY, DEPRESSION, AND NEUROPATHIC PAIN | UNIV TEXAS (US) | 2020-04-16 | — | — | US | disclosed |
| US-10450275-B2 | Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-10-22 | — | — | US | disclosed |
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299304-A1 | ANTHELMINTIC AZA-BENZOTHIOPHENE AND AZA-BENZOFURAN COMPOUNDS | TPMT, NAT1, HNMT | KCNH2 2871/4885KCNA5 1494/4885HTT 232/4885 |
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | PDE3A, PDE2A, PDE5A | KCNH2 2435/4885KCNA5 3148/4885HTT 4781/4885 |
| US-11560388-B2 | Anthelmintic aza-benzothiophene and aza-benzofuran compounds | TPMT, NAT1, HNMT | KCNH2 2871/4885KCNA5 1494/4885HTT 232/4885 |
| US-20230219974-A1 | ANTHELMINTIC AZA-BENZOTHIOPHENE AND AZA-BENZOFURAN COMPOUNDS | TPMT, NAT1, HNMT | KCNH2 2871/4885KCNA5 1494/4885HTT 232/4885 |
| US-20200115345-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER, NEUROLOGICAL DISORDERS, ETHANOL WITHDRAWAL, ANXIETY, DEPRESSION, AND NEUROPATHIC PAIN | ELAVL1, ADH1A, NGF | KCNH2 895/4885KCNA5 1314/4885HTT 716/4885 |
| US-10450275-B2 | Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain | ELAVL1, ADH1A, NGF | KCNH2 895/4885KCNA5 1314/4885HTT 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.