Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 1.00 |
| ▸ | ROCK1 | Q13464 | 2/20 | 1.00 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.71 |
| ▸ | AKT1 | P31749 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431932 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1RPS6KB1AKT1NPC1 | |
| SCHEMBL1990726 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1RPS6KB1AKT1NPC1 | |
| SCHEMBL1987717 | 0.90 | ROCK2 (0.82) | ROCK2ROCK1RPS6KB1AKT1NPC1 | |
| SCHEMBL1988716 | 0.86 | ROCK2 (0.76) | ROCK2ROCK1RPS6KB1AKT1NPC1 | |
| SCHEMBL1987182 | 0.85 | ROCK2 (0.74) | ROCK2ROCK1RPS6KB1AKT1NPC1 | |
| SCHEMBL1990954 | 0.85 | ROCK2 (0.73) | ROCK2ROCK1RPS6KB1AKT1NPC1 | |
| SCHEMBL1990960 | 0.85 | ROCK2 (0.73) | ROCK2ROCK1RPS6KB1AKT1NPC1 | |
| SCHEMBL1988377 | 0.85 | ROCK2 (0.73) | ROCK2ROCK1RPS6KB1AKT1NPC1 | |
| SCHEMBL1988376 | 0.85 | ROCK2 (0.73) | ROCK2ROCK1RPS6KB1AKT1NPC1 | |
| SCHEMBL12561553 | 0.85 | ROCK2 (0.73) | ROCK2ROCK1RPS6KB1AKT1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190328721-A1 | METHOD OF ACTIVATING DENDRITIC CELLS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-10-31 | — | — | US | claimed |
| US-20130123345-A1 | METHOD OF TREATING A VIRAL INFECTION DYSFUNCTION BY DISRUPTING AN ADENOSINE RECEPTOR PATHWAY | THE OHIO STATE UNIVERSITY (US) | 2013-05-16 | — | — | US | claimed |
| US-20240342175-A1 | Compositions and Methods for Treating Spinal Cord Injury and Synaptic Dysfunction | MITZ HOWARD (US) | 2024-10-17 | — | — | US | disclosed |
| EP-4319877-A1 | COMPOSITIONS AND METHODS FOR TREATING SPINAL CORD INJURY AND SYNAPTIC DYSFUNCTION | Mitz, Howard (US) | 2024-02-14 | — | — | EP | disclosed |
| US-11759530-B2 | TKI permeability enhancers | CITY OF HOPE (US) | 2023-09-19 | — | — | US | disclosed |
| US-11759530-B2 | TKI permeability enhancers | CITY OF HOPE (US) | 2023-09-19 | — | — | US | disclosed |
| US-20220323440-A1 | COMPOSITIONS AND METHODS FOR TREATING SPINAL CORD INJURY AND SYNAPTIC DYSFUNCTION | MITZ HOWARD (US) | 2022-10-13 | — | — | US | disclosed |
| WO-2022216537-A1 | COMPOSITIONS AND METHODS FOR TREATING SPINAL CORD INJURY AND SYNAPTIC DYSFUNCTION | MITZ HOWARD (US) | 2022-10-13 | — | — | WO | disclosed |
| US-20190328721-A1 | METHOD OF ACTIVATING DENDRITIC CELLS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-10-31 | — | — | US | disclosed |
| US-20190083650-A1 | TKI PERMEABILITY ENHANCERS | CITY OF HOPE | 2019-03-21 | — | — | US | disclosed |
| US-20180110837-A1 | METHODS AND ASSAYS RELATING TO MACROPHAGE DIFFERENTIATION | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2018-04-26 | — | — | US | disclosed |
| US-20150297679-A1 | METHODS AND ASSAYS RELATING TO MACROPHAGE DIFFERENTIATION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-22 | — | — | US | disclosed |
| WO-2014093773-A1 | METHODS AND ASSAYS RELATING TO MACROPHAGE DIFFERENTIATION | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2014-06-19 | — | — | WO | disclosed |
| WO-2014022427-A1 | INHIBITION OF RHO AND OR ROCK AND CELL TRANSPLANTATION | BIOAXONE BIOSCIENCES INC. (US) | 2014-02-06 | — | — | WO | disclosed |
| US-20130123345-A1 | METHOD OF TREATING A VIRAL INFECTION DYSFUNCTION BY DISRUPTING AN ADENOSINE RECEPTOR PATHWAY | THE OHIO STATE UNIVERSITY (US) | 2013-05-16 | — | — | US | disclosed |
| WO-2012012736-A2 | METHOD OF TREATING A VIRAL INFECTION DYSFUNCTION BY DISRUPTING AN ADENOSINE RECEPTOR PATHWAY | THE OHIO STATE UNIVERSITY (US) | 2012-01-26 | — | — | WO | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150297679-A1 | METHODS AND ASSAYS RELATING TO MACROPHAGE DIFFERENTIATION | MYADM, CD14, CD68 | ROCK2 2937/4885ROCK1 3491/4885RPS6KB1 2512/4885 |
| US-11759530-B2 | TKI permeability enhancers | ABL1, TK1, EGFR | ROCK2 275/4885ROCK1 194/4885RPS6KB1 1889/4885 |
| US-20190083650-A1 | TKI PERMEABILITY ENHANCERS | ABL1, TK1, EGFR | ROCK2 275/4885ROCK1 194/4885RPS6KB1 1889/4885 |
| US-20180110837-A1 | METHODS AND ASSAYS RELATING TO MACROPHAGE DIFFERENTIATION | MYADM, CD14, CD68 | ROCK2 2937/4885ROCK1 3491/4885RPS6KB1 2512/4885 |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | ROCK1, RHOA, RHOT2 | ROCK2 4/4885ROCK1 1/4885RPS6KB1 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.