Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 4/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CCNK | O75909 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873457 | 0.80 | AURKA (0.41) | TTKTYK2 | |
| SCHEMBL19873482 | 0.80 | EGFR (0.46) | ROCK2CAMK2DROCK1CCR2 | |
| SCHEMBL19873539 | 0.78 | RAB9A (0.42) | TYK2 | |
| SCHEMBL19873470 | 0.77 | ROCK2 (0.48) | ROCK2CAMK2D | |
| SCHEMBL19873501 | 0.76 | TYK2 (0.41) | TYK2 | |
| SCHEMBL19873522 | 0.76 | CHRNB4 (0.47) | CAMK2DCHRNB4CHRNA3 | |
| SCHEMBL19873497 | 0.76 | MAPK14 (0.35) | TTKTYK2PDE4D | |
| SCHEMBL16928307 | 0.76 | AGER (0.44) | ROCK2CAMK2DHSD17B10CCNT1CCNK | |
| SCHEMBL16928010 | 0.76 | CAMK2D (0.61) | ROCK2CAMK2DKAT2BCCR2 | |
| SCHEMBL16928472 | 0.75 | ROCK2 (0.42) | ROCK2CAMK2DROCK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351538-A1 | TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF AND METHODS FOR TREATING MALARIA AND CHEMOPROPHYLAXIS | The United States of America, as represented by The Secretary of The Army, on behalf of Walter Reed Army Institute of Research (US) | 2018-07-25 | — | — | EP | disclosed |
| EP-2970153-B1 | TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF AND METHODS FOR TREATING MALARIA AND CHEMOPROPHYLAXIS | THE US SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ARMY INSTITUTE OF RESEARCH (US) | 2018-02-21 | — | — | EP | disclosed |