Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzimidazole SCHEMBL989345 | 0.92 | ALOX12 (0.46) | SMN1; SMN2PARP1PDPK1CA12ALOX15 | |
| Benzimidazole SCHEMBL990184 | 0.92 | ALOX12 (0.46) | SMN1; SMN2PARP1PDPK1CA12ALOX15 | |
| Benzimidazole SCHEMBL1128586 | 0.89 | ALOX5AP (0.44) | SMN1; SMN2PARP1PDPK1CA12ALOX15 | |
| Benzimidazole SCHEMBL28290589 | 0.88 | MMP12 (0.42) | SMN1; SMN2PARP1PDPK1CA12ALOX15 | |
| Benzimidazole SCHEMBL29439119 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2PARP1PDPK1CA12ALOX15 | |
| Benzimidazole SCHEMBL11103578 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2PARP1PDPK1CA12ALOX15 | |
| Benzimidazole SCHEMBL28802233 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2PARP1PDPK1CA12ALOX15 | |
| Benzimidazole SCHEMBL28557779 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2PARP1PDPK1CA12ALOX15 | |
| Benzimidazole SCHEMBL11103574 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2PARP1PDPK1CA12ALOX15 | |
| Benzimidazole SCHEMBL516853 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2PARP1PDPK1CA12ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174246-B2 | Direct AMPK activators | RIGEL PHARMACEUTICALS, INC. (US) | 2021-11-16 | — | — | US | disclosed |
| EP-3500558-A1 | BENZIMIDAZOLE DIRECT AMPK ACTIVATORS | Rigel Pharmaceuticals, Inc. (US) | 2019-06-26 | — | — | EP | disclosed |
| US-20180051006-A1 | DIRECT AMPK ACTIVATORS | MIDCAP FINANCIAL TRUST | 2018-02-22 | — | — | US | disclosed |
| WO-2018035128-A1 | BENZIMIDAZOLE DIRECT AMPK ACTIVATORS | RIGEL PHARMACEUTICALS, INC. (US) | 2018-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174246-B2 | Direct AMPK activators | PRKAA1, PRKAG1, PRKAB1 | SMN1; SMN2 2477/4885PARP1 344/4885PDPK1 210/4885 |
| US-20180051006-A1 | DIRECT AMPK ACTIVATORS | PRKAA1, PRKAG1, PRKAB1 | SMN1; SMN2 2477/4885PARP1 344/4885PDPK1 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.