Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13197123 | 0.79 | ALDH1A1 (0.55) | CYP1A2CYP2C19SMN1; SMN2MAPTTP53 | |
| SCHEMBL12809631 | 0.74 | TYR (0.43) | SMN1; SMN2LMNANPSR1MEN1ALDH1A1 | |
| SCHEMBL69157 | 0.73 | MAPT (0.72) | HSD17B10CYP1A2CYP2C19SMN1; SMN2MAPT | |
| SCHEMBL20320324 | 0.72 | NPBWR1 (0.42) | SMN1; SMN2NPSR1MEN1ALDH1A1KMT2A | |
| SCHEMBL10839064 | 0.71 | MAPT (0.49) | HSD17B10CYP1A2CYP2C19SMN1; SMN2MAPT | |
| SCHEMBL4068453 | 0.71 | TSHR (0.50) | HSD17B10MAPTLMNAALDH1A1KMT2A | |
| SCHEMBL20344471 | 0.71 | CYP1A2 (0.54) | HSD17B10CYP1A2CYP2C19SMN1; SMN2MAPT | |
| SCHEMBL2680771 | 0.70 | TSHR (0.64) | CYP1A2CYP2C19SMN1; SMN2MAPTTP53 | |
| SCHEMBL31485417 | 0.70 | SMN1; SMN2 (0.53) | HSD17B10CYP1A2CYP2C19SMN1; SMN2MAPT | |
| SCHEMBL19224500 | 0.69 | CYP1A2 (0.51) | HSD17B10CYP1A2CYP2C19MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9896458-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2018-02-20 | — | — | US | disclosed |
| US-9896458-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2018-02-20 | — | — | US | disclosed |