Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 4/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.54 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17452772 | 0.89 | ALDH1A1 (0.52) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL19902350 | 0.79 | ALDH1A1 (0.57) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL19902334 | 0.79 | ALDH1A1 (0.57) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL19902533 | 0.78 | JAK1 (0.45) | KAT2BKMT2A | |
| SCHEMBL22449380 | 0.75 | ALDH1A1 (0.75) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL19902363 | 0.74 | ALDH1A1 (0.53) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL19902459 | 0.73 | CHRNA7 (0.37) | KAT2BKDM4E | |
| SCHEMBL30596797 | 0.72 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL9485783 | 0.72 | ALDH1A1 (1.00) | ALDH1A1CYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL19902578 | 0.71 | ROCK2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2018-06-07 | — | — | US | disclosed |
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | ROCK1, MYLK, ROCK2 | ALDH1A1 1252/4885CYP3A4 1654/4885TSHR 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.