Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16489213 | 0.86 | BLM (0.41) | BLMABCG2GRM4RAB9ANPC1 | |
| SCHEMBL19902804 | 0.78 | BLM (0.39) | BLMABCG2LMNAMAPTLRRK2 | |
| SCHEMBL16489233 | 0.78 | ALDH1A1 (0.47) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL16489234 | 0.76 | ALDH1A1 (0.38) | GRM4RAB9ANPC1LMNAMAPT | |
| SCHEMBL5594748 | 0.71 | P2RX7 (0.43) | P2RX7CYP2C9 | |
| SCHEMBL16489217 | 0.71 | AR (0.49) | BLM | |
| SCHEMBL1180225 | 0.70 | P2RX7 (0.53) | BLMP2RX7RAB9ANPC1MEN1 | |
| SCHEMBL19902738 | 0.69 | RAB9A (0.46) | GRM4RAB9ANPC1MEN1KMT2A | |
| SCHEMBL16722485 | 0.69 | BLM (0.51) | BLMABCG2RAB9ANPC1KMT2A | |
| SCHEMBL22626109 | 0.68 | ALDH1A1 (0.65) | BLMRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |