Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.35 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16489233 | 0.80 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTCYP1A2IMPDH2 | |
| SCHEMBL19902758 | 0.78 | BLM (0.41) | BLMABCG2ALDH1A1LMNAMAPT | |
| SCHEMBL11452798 | 0.77 | NPC1 (0.48) | ALDH1A1LMNAMAPTPOLB | |
| SCHEMBL16722485 | 0.75 | BLM (0.51) | BLMABCG2ALDH1A1LMNAGAA | |
| SCHEMBL16489213 | 0.74 | BLM (0.41) | BLMABCG2ALDH1A1LMNAGAA | |
| SCHEMBL19902737 | 0.74 | RAB9A (0.54) | ALDH1A1LMNAMAPTPOLB | |
| SCHEMBL19902764 | 0.71 | NPSR1 (0.46) | LMNAMAPT | |
| SCHEMBL19902749 | 0.71 | MAPT (0.38) | ALDH1A1LMNAMAPT | |
| SCHEMBL19902763 | 0.70 | SGMS2 (0.40) | F2RALDH1A1GAAMAPTHPGD | |
| SCHEMBL22626109 | 0.70 | ALDH1A1 (0.65) | BLMALDH1A1MAPTIMPDH2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |