Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11452798 | 0.79 | NPC1 (0.48) | RAB9ANPC1SMN1; SMN2POLBLMNA | |
| SCHEMBL4861779 | 0.72 | CA1 (0.53) | RAB9ANPC1SMN1; SMN2NAMPTL3MBTL1 | |
| SCHEMBL19902741 | 0.71 | KDM4E (0.52) | RAB9ANPC1SMN1; SMN2NAMPTL3MBTL1 | |
| SCHEMBL19902734 | 0.71 | KDM4E (0.49) | RAB9ANPC1SMN1; SMN2L3MBTL1CYP2C9 | |
| SCHEMBL19902755 | 0.71 | KMT2A (0.43) | RAB9ANPC1SMN1; SMN2NAMPTPOLB | |
| SCHEMBL19902756 | 0.71 | BLM (0.42) | RAB9ANPC1NAMPTL3MBTL1 | |
| SCHEMBL16491923 | 0.70 | KCNMA1 (0.50) | RAB9ASMN1; SMN2LMNA | |
| SCHEMBL30465486 | 0.70 | KDM4E (0.57) | RAB9AL3MBTL1POLBLMNA | |
| SCHEMBL4074620 | 0.70 | KDM4E (0.57) | RAB9AL3MBTL1POLBLMNA | |
| SCHEMBL18149317 | 0.69 | TSHR (0.52) | RAB9ANPC1NAMPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |