Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902756 | 0.90 | BLM (0.42) | NPC1RAB9ANAMPTMAPTBRAF | |
| SCHEMBL19902783 | 0.73 | SGMS2 (0.35) | KMT2ATP53NPC1RAB9AALDH1A1 | |
| SCHEMBL19902767 | 0.71 | RAB9A (0.44) | NPC1RAB9ANAMPTSMN1; SMN2POLB | |
| SCHEMBL16489237 | 0.70 | MEN1 (0.45) | KMT2ANPC1RAB9AALDH1A1NAMPT | |
| SCHEMBL5172599 | 0.69 | KMT2A (0.68) | KMT2ATP53NPC1RAB9AALDH1A1 | |
| SCHEMBL4480018 | 0.69 | LMNA (0.48) | KMT2ATP53NPC1RAB9AALDH1A1 | |
| SCHEMBL9192271 | 0.68 | MEN1 (0.73) | KMT2ATP53NPC1RAB9AALDH1A1 | |
| SCHEMBL16491933 | 0.68 | NPC1 (0.44) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL25668722 | 0.67 | KMT2A (0.69) | KMT2ATP53RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL13962554 | 0.66 | KMT2A (0.59) | KMT2ATP53NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033337-B1 | SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |